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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1994 Oct;57(10):1212–1215. doi: 10.1136/jnnp.57.10.1212

Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour.

J Yoshida 1, T Wakabayashi 1, S Okamoto 1, S Kimura 1, K Washizu 1, K Kiyosawa 1, K Mokuno 1
PMCID: PMC485489  PMID: 7523604

Abstract

Tenascin, an extracellular matrix glycoprotein, has been reported to be expressed predominantly on glioma tissue in the CNS, both in a cell associated and an excreted form. Recently, a highly sensitive sandwich type enzyme immunoassay for quantitative determination of tenascin was developed. In the present study, the amount of tenascin in CSF was measured. An increase of tenascin in CSF (> 100 ng/ml) was found in patients with an astrocytic tumour. The concentration was significantly higher (> 300 ng/ml) in high grade astrocytoma (anaplastic astrocytoma and glioblastoma) and a further increase (> 1000 ng/ml) was found in cases of CSF dissemination of high grade astrocytoma. On the other hand, tenascin concentrations were less than 100 ng/ml in non-astrocytic tumours and non-neoplastic neurological diseases, except meningeal dissemination of tumour cells, meningeal stimulation by infection, and subarachnoid haemorrhage. In cases of treated astrocytomas in remission, tenascin was negligible (< 100 ng/ml) in the CSF. The measurement of tenascin in CSF is useful for differential diagnosis of brain tumours and monitoring of astrocytic tumours.

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Selected References

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  1. Bourdon M. A., Matthews T. J., Pizzo S. V., Bigner D. D. Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein. J Cell Biochem. 1985;28(3):183–195. doi: 10.1002/jcb.240280302. [DOI] [PubMed] [Google Scholar]
  2. Bourdon M. A., Wikstrand C. J., Furthmayr H., Matthews T. J., Bigner D. D. Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. Cancer Res. 1983 Jun;43(6):2796–2805. [PubMed] [Google Scholar]
  3. Chiquet-Ehrismann R., Mackie E. J., Pearson C. A., Sakakura T. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell. 1986 Oct 10;47(1):131–139. doi: 10.1016/0092-8674(86)90374-0. [DOI] [PubMed] [Google Scholar]
  4. Chiquet M., Fambrough D. M. Chick myotendinous antigen. I. A monoclonal antibody as a marker for tendon and muscle morphogenesis. J Cell Biol. 1984 Jun;98(6):1926–1936. doi: 10.1083/jcb.98.6.1926. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Erickson H. P., Taylor H. C. Hexabrachion proteins in embryonic chicken tissues and human tumors. J Cell Biol. 1987 Sep;105(3):1387–1394. doi: 10.1083/jcb.105.3.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grumet M., Hoffman S., Crossin K. L., Edelman G. M. Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. Proc Natl Acad Sci U S A. 1985 Dec;82(23):8075–8079. doi: 10.1073/pnas.82.23.8075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kruse J., Keilhauer G., Faissner A., Timpl R., Schachner M. The J1 glycoprotein--a novel nervous system cell adhesion molecule of the L2/HNK-1 family. Nature. 1985 Jul 11;316(6024):146–148. doi: 10.1038/316146a0. [DOI] [PubMed] [Google Scholar]
  8. Lightner V. A., Gumkowski F., Bigner D. D., Erickson H. P. Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy. J Cell Biol. 1989 Jun;108(6):2483–2493. doi: 10.1083/jcb.108.6.2483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Oike Y., Hiraiwa H., Kawakatsu H., Nishikai M., Okinaka T., Suzuki T., Okada A., Yatani R., Sakakura T. Isolation and characterization of human fibroblast tenascin. An extracellular matrix glycoprotein of interest for developmental studies. Int J Dev Biol. 1990 Jun;34(2):309–317. [PubMed] [Google Scholar]
  10. Ventimiglia J. B., Wikstrand C. J., Ostrowski L. E., Bourdon M. A., Lightner V. A., Bigner D. D. Tenascin expression in human glioma cell lines and normal tissues. J Neuroimmunol. 1992 Jan;36(1):41–55. doi: 10.1016/0165-5728(92)90029-k. [DOI] [PubMed] [Google Scholar]
  11. Yoshida J., Yamamoto R., Wakabayashi T., Nagata M., Seo H. Radioimmunoassay of glioma-associated antigen in cerebrospinal fluid and its usefulness for the diagnosis and monitoring of human glioma. J Neurooncol. 1990 Feb;8(1):23–31. doi: 10.1007/BF00182083. [DOI] [PubMed] [Google Scholar]

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