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. 2016 May 3;13:32. doi: 10.1186/s12977-016-0266-9

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© Antell et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Statistically divergent Tat positions demonstrate reduced diversity within X4-classified sequences. Within HIV-1 Tat, four amino acid positions were identified as having statistically significant Jensen–Shannon divergence: 7, 23, 57, and 60. In all four cases, it was noted that X4-classified variants exhibited a lower overall genetic diversity at an order of 1, largely due to the enhanced presence of the most common variant in the X4 population. This pattern of diminished diversity within X4 in comparison to R5 suggests that a purifying selective force may be present, affecting a subset of HIV-1 Tat variants