In utero supplementation with methyl donors enhances allergic airway disease in mice

Original citation: J Clin Invest. 2008;118(10):3462–3469. doi:10.1172/JCI34378.

Citation for this retraction: J Clin Invest. 2016;126(5):2012. doi:10.1172/JCI87742.

At the request of the corresponding author, John W. Hollingsworth, and the last author, David A. Schwartz, the JCI is retracting this paper. Following an inquiry at Duke University, Drs. Hollingsworth and Schwartz were informed that the flexiVent data depicted in Figure 1A and Supplemental Figure 1A provided by the animal pulmonary physiology laboratory at Duke University may have been unreliable. Dr. Schwartz therefore repeated the experiments shown in Figure 1A using different flexiVent equipment with a limited number of experimental animals and was unable to replicate the airway hyperresponsiveness findings. The authors have stated that the other findings presented in the article were generated and analyzed in Dr. Schwartz’s laboratory and are not affected by the unreliable flexiVent data produced by the animal pulmonary physiology laboratory at Duke University.