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. Author manuscript; available in PMC: 2016 May 4.
Published in final edited form as: Biopolymers. 2015 Jul;104(4):334–350. doi: 10.1002/bip.22639

FIGURE 12.

FIGURE 12

Design of a tetrahedron/trigonal pyramid using coiled-coils assembly. (a) Cartoon illustrating the pyramid components—sets of heterodimeric and homodimeric parallel and anti-parallel coiled-coils. The 12 individual peptide sequences are concatenated in the indicated order, with each sequence separated by the flexible linker Ser-Gly-Pro-Gly. Grey lines indicate the interacting pairs. (b) Schematic of the desired tetrahedron structure. Arrows indicate the direction of the helices in the coiled-coil pairs. Reprinted by permission from Macmillan Publishers Ltd: [Nature Chemical Biology] Gradisar, H.; Bozic, S.; Doles, T.; Vengust, D.; Hafner-Bratkovic, I.; Mertelj, A.; Webb, B.; Sali, A.; Klavzar, S.; Jerala, R. Nat Chem Biol 2013, 9, 362–366, © 2013.