Fig. 4.

Sensitivity analysis of the associations of genetically determined T2D with decreased eGFR and increased uACR. Data were presented as odds ratios (ORs) and 95% confidence intervals (CIs). P values were adjusted for age (years), sex, BMI (kg/m²), current smoking (yes or no), current drinking (yes or no), physical activity (mild, moderate or vigorous), hypertension (yes or no), total cholesterol (mmol/l), HDL-cholesterol (mmol/l), LDL-cholesterol (mmol/l) and triglycerides (mmol/l). T2D_GRS: type 2 diabetes genetic risk score; SD: standard deviation. T2D_GRS_{/25 SNP} was calculated from the SNPs after excluding those were out of Hardy–Weinberg equilibrium (rs1801282, rs831571, rs6467136, rs864745, rs13266634, rs89654, rs17584499, rs111187 and rs1552224). T2D_GRS_{/18 SNP} was calculated using the SNPs after excluding those may have potential pleiotropic effects (rs5215, rs4402960, rs1111875, rs243021, rs231362, rs10906115, rs3786897, rs9356744, rs17817449, rs6017317, rs17584499, rs2191349, rs1552224, rs7612463, rs13266634 and rs780094).