Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding

Nucl. Acids Res. 44 (2): 983–991. doi: 10.1093/nar/gkv1384

The authors wish to make the following corrections to their article:

Table 2 was calculated on an initial model of the complex in which the nucleotide sequence was not correct. Tables 1 and 3 were based on the correct model deposited into PDB and are therefore correct. A new Table 2 based on the PDB model is provided below and supersedes the published Table.

Table 2. Stacking interactions as calculated by 3DNA-DSSR (41) among residues belonging to the duplex, the junction and the quadruplex of RE31.

Nucleotide 1	Nucleotide 2	Structural motif	Base stacking (Å2)*
Thy2	Gua3	Duplex	4.5
Gua3	Ade4	Duplex	3.7
Ade4	Cyt5	Duplex	3.4
Cyt5	Gua6	Duplex	1.4
Gua6	Thy7	Junction	7.0
Thy7	Thy17	Junction	7.4
Thy17	Gua16	Junction	8.0
Gua16	Gua14	Junction	3.2
Gua14	Gua13	Quadruplex	4.4
Ade30	Cyt29	Duplex	1.3
Cyt29	Thy28	Duplex	7.1
Thy28	Gua27	Duplex	7.0
Gua27	Cyt26	Duplex	1.3
Cyt26	Gua25	Junction	4.6
Gua25	Ade8	Junction	2.2
Ade8	Gua24	Junction	4.6
Gua24	Gua23	Junction	2.5
Gua23	Gua22	Quadruplex	4.3

*Base-stacking is quantified as the area of the overlapped polygon defined by the two bases of the interacting nucleotides, where the base atoms are projected onto the mean base plane.