Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1995 Sep;59(3):248–252. doi: 10.1136/jnnp.59.3.248

Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double blind, placebo controlled study.

L H Van den Berg 1, H Kerkhoff 1, P L Oey 1, H Franssen 1, I Mollee 1, M Vermeulen 1, F G Jennekens 1, J H Wokke 1
PMCID: PMC486021  PMID: 7673950

Abstract

The effect of high dose intravenous immunoglobulin (IVIg) treatment was studied in six patients with multifocal motor neuropathy (MMN). All patients responded to treatment (0.4 g/kg for five consecutive days) in an open trial. The effect of IVIg treatment was confirmed for each patient in a single patient, double blind, placebo controlled trial. Four patients received two IVIg treatments and two placebo treatments, and two patients received one IVIg and one placebo treatment in a randomised order. Five out of six patients responded to IVIg but not to placebo. One patient responded to IVIg in the same manner as to placebo treatment. Thus IVIg treatment can lead to improvement of muscle strength in patients with MMN.

Full text

PDF
248

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Azulay J. P., Blin O., Pouget J., Boucraut J., Billé-Turc F., Carles G., Serratrice G. Intravenous immunoglobulin treatment in patients with motor neuron syndromes associated with anti-GM1 antibodies: a double-blind, placebo-controlled study. Neurology. 1994 Mar;44(3 Pt 1):429–432. doi: 10.1212/wnl.44.3_part_1.429. [DOI] [PubMed] [Google Scholar]
  2. Chaudhry V., Corse A. M., Cornblath D. R., Kuncl R. W., Drachman D. B., Freimer M. L., Miller R. G., Griffin J. W. Multifocal motor neuropathy: response to human immune globulin. Ann Neurol. 1993 Mar;33(3):237–242. doi: 10.1002/ana.410330303. [DOI] [PubMed] [Google Scholar]
  3. Krarup C., Stewart J. D., Sumner A. J., Pestronk A., Lipton S. A. A syndrome of asymmetric limb weakness with motor conduction block. Neurology. 1990 Jan;40(1):118–127. doi: 10.1212/wnl.40.1.118. [DOI] [PubMed] [Google Scholar]
  4. Lange D. J., Trojaborg W., Latov N., Hays A. P., Younger D. S., Uncini A., Blake D. M., Hirano M., Burns S. M., Lovelace R. E. Multifocal motor neuropathy with conduction block: is it a distinct clinical entity? Neurology. 1992 Mar;42(3 Pt 1):497–505. doi: 10.1212/wnl.42.3.497. [DOI] [PubMed] [Google Scholar]
  5. McLeod R. S., Taylor D. W., Cohen Z., Cullen J. B. Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir. Lancet. 1986 Mar 29;1(8483):726–728. doi: 10.1016/s0140-6736(86)91112-8. [DOI] [PubMed] [Google Scholar]
  6. Nobile-Orazio E., Meucci N., Barbieri S., Carpo M., Scarlato G. High-dose intravenous immunoglobulin therapy in multifocal motor neuropathy. Neurology. 1993 Mar;43(3 Pt 1):537–544. doi: 10.1212/wnl.43.3_part_1.537. [DOI] [PubMed] [Google Scholar]
  7. Pestronk A., Cornblath D. R., Ilyas A. A., Baba H., Quarles R. H., Griffin J. W., Alderson K., Adams R. N. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. Ann Neurol. 1988 Jul;24(1):73–78. doi: 10.1002/ana.410240113. [DOI] [PubMed] [Google Scholar]
  8. Rhee E. K., England J. D., Sumner A. J. A computer simulation of conduction block: effects produced by actual block versus interphase cancellation. Ann Neurol. 1990 Aug;28(2):146–156. doi: 10.1002/ana.410280206. [DOI] [PubMed] [Google Scholar]
  9. Rowland L. P. Amyotrophic lateral sclerosis: theories and therapies. Ann Neurol. 1994 Feb;35(2):129–130. doi: 10.1002/ana.410350202. [DOI] [PubMed] [Google Scholar]
  10. Willison H. J. Antiglycolipid antibodies in peripheral neuropathy: fact or fiction? J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1303–1307. doi: 10.1136/jnnp.57.11.1303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. van Doorn P. A., Vermeulen M., Brand A., Mulder P. G., Busch H. F. Intravenous immunoglobulin treatment in patients with chronic inflammatory demyelinating polyneuropathy. Clinical and laboratory characteristics associated with improvement. Arch Neurol. 1991 Feb;48(2):217–220. doi: 10.1001/archneur.1991.00530140113024. [DOI] [PubMed] [Google Scholar]
  12. van Swieten J. C., Koudstaal P. J., Visser M. C., Schouten H. J., van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988 May;19(5):604–607. doi: 10.1161/01.str.19.5.604. [DOI] [PubMed] [Google Scholar]
  13. van der Ploeg R. J., Fidler V., Oosterhuis H. J. Hand-held myometry: reference values. J Neurol Neurosurg Psychiatry. 1991 Mar;54(3):244–247. doi: 10.1136/jnnp.54.3.244. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES