Abstract
Seven children with acute disseminated encephalomyelitis (ADEM) after treatment with Japanese B encephalitis vaccine (JBEV) (Nakayama-Yoken strain 1968-88 and Beijing strain 1989-93) were identified by mailed questionnaires and by compilation of previously published case reports. It was considered that encephalomyelitis might have been related to vaccine treatment as the vaccine is derived from mouse brain tissue infected with Japanese B encephalitis virus, a potentially cross reactive antigen. The incidence of severe neurological complications associated with the newer Japanese B encephalitis Beijing strain vaccine seemed to be less than one case per 1,000,000, which is similar to the incidence of neurological complications associated with the older Nakayama-Yoken strain vaccine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hoke C. H., Nisalak A., Sangawhipa N., Jatanasen S., Laorakapongse T., Innis B. L., Kotchasenee S., Gingrich J. B., Latendresse J., Fukai K. Protection against Japanese encephalitis by inactivated vaccines. N Engl J Med. 1988 Sep 8;319(10):608–614. doi: 10.1056/NEJM198809083191004. [DOI] [PubMed] [Google Scholar]
- Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
- Ohtaki E., Murakami Y., Komori H., Yamashita Y., Matsuishi T. Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination. Pediatr Neurol. 1992 Mar-Apr;8(2):137–139. doi: 10.1016/0887-8994(92)90036-x. [DOI] [PubMed] [Google Scholar]
- Okinaka S., Toyokura Y., Tsukagoshi H., Kuriowa Y., Araki S. [Physical reactions following vaccination against Japanese B encephalitis--with special reference to neurological complications]. Shinkei Kenkyu No Shimpo. 1967 Aug;11(2):410–424. [PubMed] [Google Scholar]