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. 1995 Oct;59(4):395–399. doi: 10.1136/jnnp.59.4.395

Spastic tetraplegia as an initial manifestation of familial Alzheimer's disease.

N Sodeyama 1, M Shimada 1, T Uchihara 1, K Yanagisawa 1, H Fujigasaki 1, K Yamaguchi 1, M Matsushita 1, M Yamada 1
PMCID: PMC486076  PMID: 7561919

Abstract

Two sisters with familial Alzheimer's disease developed spastic gait disturbance as an initial manifestation. Their gait disturbance progressed gradually, followed by dementia a few years later. Post-mortem examination of one of the patients disclosed degeneration of the thalamus and corticospinal tract in addition to numerous senile plaques and neurofibrillary tangles in the neocortex, both of which were confirmed by immunohistochemistry. This is the first report in which clinicopathological evaluation is sufficient to establish a new variant of Alzheimer's disease presenting initially as spastic tetraplegia.

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Selected References

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