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IL-6 was elevated in serum and local tumor site in a short time after therapy. (A) IL-6 was identified as the upstream regulator of acute phase proteins. (B) The amount of IL-6 in serum was measured by ELISA. (C) The expression of IL-6 within tumors was examined with RT-PCR. Data are shown as mean ± SD. **p < 0.01, by (B) two-way ANOVA with the Bonferroni correction; n=3 with two replicates assay. (C) Student t test. Triple replicates assay.
