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. 1996 May;60(5):564–571. doi: 10.1136/jnnp.60.5.564

Cognitive function in patients with Parkinson's disease undergoing stereotaxic thalamotomy.

M Lund-Johansen 1, K Hugdahl 1, K Wester 1
PMCID: PMC486373  PMID: 8778265

Abstract

OBJECTIVE--To determine whether thalamotomy leads to cognitive disturbances in patients with Parkinson's disease. METHODS--A total of 53 patients with Parkinson's disease undergoing stereotaxic ventrolateral thalamotomy for tremor and rigidity were tested for cognitive functions before and after surgery. The cognitive functions investigated involved visuospatial perception and memory. verbal memory, attention shift, and executive functions including set maintenance and shift. A neuropsychological test battery was used that contained the Wisconsin card sorting test, Street completion test, Stroop test, a dichotic memory listening test, and a facial recognition test. RESULTS--Clinically, a good or moderately good effect on parkinsonian symptoms was obtained in 50 patients. The neuropsychological investigations showed that the patients were impaired compared with healthy age matched control subjects on most tests, showing slight improvement postoperatively on verbal memory and visuospatial perception. No major differences were found between tests before and after operation, and there were no significant differences between patients undergoing surgery in the right or in the left thalamus. CONCLUSION--The study indicates that ventrolateral thalamotomy does not reduce the cognitive capacity in this group of patients.

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Selected References

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  1. Almgren P. E., Andersson A. L., Kullberg G. Differences in verbally expressed cognition following left and right ventrolateral thalamotomy. Scand J Psychol. 1969;10(4):243–249. doi: 10.1111/j.1467-9450.1969.tb00033.x. [DOI] [PubMed] [Google Scholar]
  2. Bowen F. P., Hoehn M. M., Yahr M. D. Parkinsonism: alterations in spatial orientation as determined by a route-walking test. Neuropsychologia. 1972 Sep;10(3):355–361. doi: 10.1016/0028-3932(72)90027-9. [DOI] [PubMed] [Google Scholar]
  3. Brown R. G., Marsden C. D. Internal versus external cues and the control of attention in Parkinson's disease. Brain. 1988 Apr;111(Pt 2):323–345. doi: 10.1093/brain/111.2.323. [DOI] [PubMed] [Google Scholar]
  4. Brown R. G., Marsden C. D. Visuospatial function in Parkinson's disease. Brain. 1986 Oct;109(Pt 5):987–1002. doi: 10.1093/brain/109.5.987. [DOI] [PubMed] [Google Scholar]
  5. Christianson S. A., Nilsson L. G., Silfvenius H. Initial memory deficits and subsequent recovery in two cases of head trauma. Scand J Psychol. 1987;28(4):267–280. doi: 10.1111/j.1467-9450.1987.tb00764.x. [DOI] [PubMed] [Google Scholar]
  6. Crosson B. Role of the dominant thalamus in language: a review. Psychol Bull. 1984 Nov;96(3):491–517. [PubMed] [Google Scholar]
  7. Danta G., Hilton R. C. Judgment of the visual vertical and horizontal in patients with Parkinsonism. Neurology. 1975 Jan;25(1):43–47. doi: 10.1212/wnl.25.1.43. [DOI] [PubMed] [Google Scholar]
  8. De Renzi E., Spinnler H. Visual recognition in patients with unilateral cerebral disease. J Nerv Ment Dis. 1966 Jun;142(6):515–525. doi: 10.1097/00005053-196606000-00002. [DOI] [PubMed] [Google Scholar]
  9. Della Sala S., Di Lorenzo G., Giordano A., Spinnler H. Is there a specific visuo-spatial impairment in Parkinsonians? J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1258–1265. doi: 10.1136/jnnp.49.11.1258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hirai T., Miyazaki M., Nakajima H., Shibazaki T., Ohye C. The correlation between tremor characteristics and the predicted volume of effective lesions in stereotaxic nucleus ventralis intermedius thalamotomy. Brain. 1983 Dec;106(Pt 4):1001–1018. doi: 10.1093/brain/106.4.1001. [DOI] [PubMed] [Google Scholar]
  11. Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427–442. doi: 10.1212/wnl.17.5.427. [DOI] [PubMed] [Google Scholar]
  12. Hugdahl K., Iversen P. M., Ness H. M., Flaten M. A. Hemispheric differences in recognition of facial expressions: a VHF-study of negative, positive, and neutral emotions. Int J Neurosci. 1989 Apr;45(3-4):205–213. doi: 10.3109/00207458908986233. [DOI] [PubMed] [Google Scholar]
  13. Hugdahl K., Wester K., Asbjørnsen A. The role of the left and right thalamus in language asymmetry: dichotic listening in Parkinson patients undergoing stereotactic thalamotomy. Brain Lang. 1990 Jul;39(1):1–13. doi: 10.1016/0093-934x(90)90001-w. [DOI] [PubMed] [Google Scholar]
  14. Hugdahl K., Wester K. Dichotic listening studies of hemispheric asymmetry in brain damaged patients. Int J Neurosci. 1992 Mar;63(1-2):17–29. doi: 10.3109/00207459208986657. [DOI] [PubMed] [Google Scholar]
  15. Laitinen L. V. Brain targets in surgery for Parkinson's disease. Results of a survey of neurosurgeons. J Neurosurg. 1985 Mar;62(3):349–351. doi: 10.3171/jns.1985.62.3.0349. [DOI] [PubMed] [Google Scholar]
  16. Lichter D. G., Corbett A. J., Fitzgibbon G. M., Davidson O. R., Hope J. K., Goddard G. V., Sharples K. J., Pollock M. Cognitive and motor dysfunction in Parkinson's disease. Clinical, performance, and computed tomographic correlations. Arch Neurol. 1988 Aug;45(8):854–860. doi: 10.1001/archneur.1988.00520320040013. [DOI] [PubMed] [Google Scholar]
  17. Magnussen S., Sunde B., Dyrnes S. Patterns of perceptual asymmetry in processing facial expression. Cortex. 1994 Jun;30(2):215–229. doi: 10.1016/s0010-9452(13)80194-3. [DOI] [PubMed] [Google Scholar]
  18. Matsumoto K., Shichijo F., Fukami T. Long-term follow-up review of cases of Parkinson's disease after unilateral or bilateral thalamotomy. J Neurosurg. 1984 May;60(5):1033–1044. doi: 10.3171/jns.1984.60.5.1033. [DOI] [PubMed] [Google Scholar]
  19. Raczkowski D., Kalat J. W., Nebes R. Reliability and validity of some handedness questionnaire items. Neuropsychologia. 1974 Jan;12(1):43–47. doi: 10.1016/0028-3932(74)90025-6. [DOI] [PubMed] [Google Scholar]
  20. Samra K., Riklan M., Levita E., Zimmerman J., Waltz J. M., Bergmann L., Cooper I. S. Language and speech correlates of anatomically verified lesions in thalamic surgery for parkinsonism. J Speech Hear Res. 1969 Sep;12(3):510–540. doi: 10.1044/jshr.1203.510. [DOI] [PubMed] [Google Scholar]
  21. Selby G. Stereotactic surgery for the relief of Parkinson's disease. 1. A critical review. J Neurol Sci. 1967 Sep-Oct;5(2):315–342. doi: 10.1016/0022-510x(67)90139-6. [DOI] [PubMed] [Google Scholar]
  22. Selby G. Stereotactic surgery for the relief of Parkinson's disease. 2. An analysis of the results in a series of 303 patients (413 operations). J Neurol Sci. 1967 Sep-Oct;5(2):343–375. doi: 10.1016/0022-510x(67)90140-2. [DOI] [PubMed] [Google Scholar]
  23. Taylor A. E., Saint-Cyr J. A., Lang A. E. Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow. Brain. 1986 Oct;109(Pt 5):845–883. doi: 10.1093/brain/109.5.845. [DOI] [PubMed] [Google Scholar]
  24. Vilkki J. Visual hemi-inattention after ventrolateral thalamotomy. Neuropsychologia. 1984;22(4):399–408. doi: 10.1016/0028-3932(84)90035-6. [DOI] [PubMed] [Google Scholar]
  25. Wester K., Hauglie-Hanssen E. Stereotaxic thalamotomy--experiences from the levodopa era. J Neurol Neurosurg Psychiatry. 1990 May;53(5):427–430. doi: 10.1136/jnnp.53.5.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wester K., Hauglie-Hanssen E. The prognostic value of intra-operative observations during thalamotomy for parkinsonian tremor. Clin Neurol Neurosurg. 1992;94(1):25–30. doi: 10.1016/0303-8467(92)90114-i. [DOI] [PubMed] [Google Scholar]
  27. Wester K., Hugdahl K. Arachnoid cysts of the left temporal fossa: impaired preoperative cognition and postoperative improvement. J Neurol Neurosurg Psychiatry. 1995 Sep;59(3):293–298. doi: 10.1136/jnnp.59.3.293. [DOI] [PMC free article] [PubMed] [Google Scholar]

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