Table 1. The Model Parameters Derived from the Fourier Coefficients Describe the Mean Water/Ethanol Intake During 5-min Intervals (intake: in ml/kg of body weight for water, and in grams of pure alcohol per kg of body weight for each ethanol solution) and the Number of Maximal Intake Peak Occurrences in 1 h (frequency).
| Treatment | Fourier coefficients | Water | 5% EtOH | 10% EtOH | 20% EtOH |
|---|---|---|---|---|---|
| Baseline | |||||
| Intake Frequency | 0.108 0.044 | 0.001 0.044 | 0.003 0.043 | 0.001 0.044 | |
| ADE, day 1 | |||||
| Control | Intake Frequency | 0.009+ 0.042 | 0.004+ 0.284+ | 0.004 1.030+ | 0.001 1.419+ |
| Agomelatine/ ZT12 | Intake Frequency | 0.030*,+ 0.042 | 0.003+ 0.043* | 0.005 0.094*,+ | 0.002 0.108*,+ |
| Melatonin/ ZT12 | Intake Frequency | 0.016*,+ 0.873*,+ | 0.004+ 0.048* | 0.005 0.140*,+ | 0.002 0.044* |
| Melatonin/ ZT0 | Intake Frequency | 0.075* 0.051 | 0.002+ 0.042* | 0.001*,+ 0.252*,+ | 0.001 0.272*,+ |
| SB242084/ ZT12 | Intake Frequency | 0.065*,+ 0.054 | 0.002*,+ 0.064*,+ | 0.005 0.005*,+ | 0.004*,+ 0.213*,+ |
The table shows the Fourier coefficients calculated for the last 3 days of baseline drinking (Baseline) and the first post-abstinence day (ADE, day 1) in vehicle-treated rats and drug-treated rat groups (note: during the baseline and vehicle treatment conditions all groups of rats had nearly identical Fourier coefficients, therefore average coefficients for all control groups are presented in the table). ZT12 indicates that drugs were administered at the end of the light phase, ZT0 indicates that drugs were administered at the onset of the light phase, *indicates significant difference from the vehicle control group, +indicates significant differences from the baseline condition, P<0.05.