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. 2015 Jul 1;40(13):2993–3005. doi: 10.1038/npp.2015.155

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Copyright © 2015 American College of Neuropsychopharmacology

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third partymaterial in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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DMR-associated genes and genes involved in synaptic plasticity and synaptic transmission interact with common PPIhubs. (a) Heatmap showing Fisher's exact test P-values from PPIhub enrichment analyses (calculated by Lists2Networks (Lachmann and Ma'ayan, 2010)) using three gene sets: DMR-associated genes (n=492), and genes in GO categories GO:0048167 (‘regulation of synaptic plasticity' n=146) and GO:0035249 (‘glutamatergic synaptic transmission' n=79). Only PPIhubs for which a significant enrichment (P<0.05) was found for the DMR gene set are shown. (b) Protein interaction network including proteins corresponding to genes from DMR, GO:0048167, and GO:0035249 sets that interact with Dlg4, based on known interactions from rat, mouse, and human interaction databases (Berger et al, 2007; Lachmann and Ma'ayan, 2010). Proteins are colored according to whether they belong to one or more of the three gene sets. DMR, differentially methylated region.