Abstract
Vinorelbine (5'-noranhydrovinblastine) is a new semisynthetic antineoplastic vinca alkaloid which interfers with axonal transport, inducing spiralisation of axonal microtubules and resulting in peripheral neurotoxicity. A prospective detailed neurological and electrophysiological evaluation was performed in 23 patients treated with 25 mg vinorelbine a week. All patients developed a sensory-motor distal symmetric axonal neuropathy. The neurotoxicity increased with cumulative vinorelbine doses and peripheral neuropathy was mild or moderate in most patients. After discontinuation of vinorelbine treatment, neuropathic signs and symptoms were partially reversible.
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- Chaudhry V., Rowinsky E. K., Sartorius S. E., Donehower R. C., Cornblath D. R. Peripheral neuropathy from taxol and cisplatin combination chemotherapy: clinical and electrophysiological studies. Ann Neurol. 1994 Mar;35(3):304–311. doi: 10.1002/ana.410350310. [DOI] [PubMed] [Google Scholar]
- Cvitkovic E., Izzo J. The current and future place of vinorelbine in cancer therapy. Drugs. 1992;44 (Suppl 4):36–69. doi: 10.2165/00003495-199200444-00005. [DOI] [PubMed] [Google Scholar]
- Dyck P. J., Sherman W. R., Hallcher L. M., Service F. J., O'Brien P. C., Grina L. A., Palumbo P. J., Swanson C. J. Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry. Ann Neurol. 1980 Dec;8(6):590–596. doi: 10.1002/ana.410080608. [DOI] [PubMed] [Google Scholar]
- Gasparini G., Caffo O., Barni S., Frontini L., Testolin A., Guglielmi R. B., Ambrosini G. Vinorelbine is an active antiproliferative agent in pretreated advanced breast cancer patients: a phase II study. J Clin Oncol. 1994 Oct;12(10):2094–2101. doi: 10.1200/JCO.1994.12.10.2094. [DOI] [PubMed] [Google Scholar]
- Oken M. M., Creech R. H., Tormey D. C., Horton J., Davis T. E., McFadden E. T., Carbone P. P. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982 Dec;5(6):649–655. [PubMed] [Google Scholar]
- Schaumburg H. H., Spencer P. S. Toxic neuropathies. Neurology. 1979 Apr;29(4):429–431. doi: 10.1212/wnl.29.4.429. [DOI] [PubMed] [Google Scholar]
- Shahani B. T., Halperin J. J., Boulu P., Cohen J. Sympathetic skin response--a method of assessing unmyelinated axon dysfunction in peripheral neuropathies. J Neurol Neurosurg Psychiatry. 1984 May;47(5):536–542. doi: 10.1136/jnnp.47.5.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Windebank A. J., Smith A. G., Russell J. W. The effect of nerve growth factor, ciliary neurotrophic factor, and ACTH analogs on cisplatin neurotoxicity in vitro. Neurology. 1994 Mar;44(3 Pt 1):488–494. doi: 10.1212/wnl.44.3_part_1.488. [DOI] [PubMed] [Google Scholar]
- Zhou X. J., Rahmani R. Preclinical and clinical pharmacology of vinca alkaloids. Drugs. 1992;44 (Suppl 4):1–69. doi: 10.2165/00003495-199200444-00002. [DOI] [PubMed] [Google Scholar]