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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Biomaterials. 2016 Feb 10;87:157–169. doi: 10.1016/j.biomaterials.2016.02.013

Figure 8.

Figure 8

Qualitative Morphological Examination (25 μm thick Z-projections). a) Microglia in non-implanted control tissue shows extended radial processes. b–c) Microglial cells around aCSF perfused microdialysis probes show a reduced number of processes that are extended towards the probe surface when compared to previous silicon study [33]. d) Microglia around Dex perfused microdialysis probes generally maintains greater level of radially extended processes. However, these processes typically have thicker basal processes and increased apical processes giving a bushier appearance when compared to ramified control (a). e) In one example, microglial cells appeared more amoeboid with substantially reduced number of processes. While the number of processes encapsulating the probe is greatly reduced, the morphology of these cells appear very differently from a–d. Note: e is the same probe and Dex concentration as d (other side of the probe). Microdialysis probe is outlined in blue. Scale = 100 μm.