Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1996 Dec;61(6):632–635. doi: 10.1136/jnnp.61.6.632

Spinal cord MRI in multiple sclerosis with multicoil arrays: a comparison between fast spin echo and fast FLAIR.

M Filippi 1, T A Yousry 1, H Alkadhi 1, M Stehling 1, M A Horsfield 1, R Voltz 1
PMCID: PMC486662  PMID: 8971115

Abstract

OBJECTIVES: To compare the sensitivity of fast spin echo (FSE) and of fast fluid attenuated inversion recovery (fast FLAIR) in detecting spinal cord lesions in multiple sclerosis. METHODS: With a 1.5 Tesla machine and a multicoil receiver array, FSE images (with two different pixel sizes) and fast FLAIR images of the spinal cord were obtained from 13 patients with multiple sclerosis. RESULTS: Twenty three lesions (10 cervical, 12 thoracic, and one lumbar) were found in seven patients (54%) using FSE with the larger pixel size. Seventeen lesions (seven cervical and 10 thoracic) were detected in the same seven patients using FSE with smaller pixel size. Nine lesions (five cervical and four thoracic) were found using fast FLAIR in six patients (46%). All the lesions found using fast FLAIR were detected using the other two techniques and all the lesions detected by FSE with smaller pixel size were detected using FSE and greater pixel size. CONCLUSION: Fast FLAIR sequences detect substantially fewer cord lesions in patients with multiple sclerosis.

Full text

PDF
632

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baratti C., Barkhof F., Hoogenraad F., Valk J. Partially saturated fluid attenuated inversion recovery (FLAIR) sequences in multiple sclerosis: comparison with fully relaxed FLAIR and conventional spin-echo. Magn Reson Imaging. 1995;13(4):513–521. doi: 10.1016/0730-725x(95)00009-6. [DOI] [PubMed] [Google Scholar]
  2. Constable R. T., Gore J. C. The loss of small objects in variable TE imaging: implications for FSE, RARE, and EPI. Magn Reson Med. 1992 Nov;28(1):9–24. doi: 10.1002/mrm.1910280103. [DOI] [PubMed] [Google Scholar]
  3. Filippi M., Horsfield M. A., Tofts P. S., Barkhof F., Thompson A. J., Miller D. H. Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis. Brain. 1995 Dec;118(Pt 6):1601–1612. doi: 10.1093/brain/118.6.1601. [DOI] [PubMed] [Google Scholar]
  4. Filippi M., Yousry T., Baratti C., Horsfield M. A., Mammi S., Becker C., Voltz R., Spuler S., Campi A., Reiser M. F. Quantitative assessment of MRI lesion load in multiple sclerosis. A comparison of conventional spin-echo with fast fluid-attenuated inversion recovery. Brain. 1996 Aug;119(Pt 4):1349–1355. doi: 10.1093/brain/119.4.1349. [DOI] [PubMed] [Google Scholar]
  5. Finelli D. A., Hurst G. C., Karaman B. A., Simon J. E., Duerk J. L., Bellon E. M. Use of magnetization transfer for improved contrast on gradient-echo MR images of the cervical spine. Radiology. 1994 Oct;193(1):165–171. doi: 10.1148/radiology.193.1.8090886. [DOI] [PubMed] [Google Scholar]
  6. Hashemi R. H., Bradley W. G., Jr, Chen D. Y., Jordan J. E., Queralt J. A., Cheng A. E., Henrie J. N. Suspected multiple sclerosis: MR imaging with a thin-section fast FLAIR pulse sequence. Radiology. 1995 Aug;196(2):505–510. doi: 10.1148/radiology.196.2.7617868. [DOI] [PubMed] [Google Scholar]
  7. Ho P. S., Yu S. W., Czervionke L. F., Sether L. A., Wagner M., Pech P., Haughton V. M. MR appearance of gray and white matter at the cervicomedullary region. AJNR Am J Neuroradiol. 1989 Sep-Oct;10(5):1051–1055. [PMC free article] [PubMed] [Google Scholar]
  8. Kidd D., Thorpe J. W., Thompson A. J., Kendall B. E., Moseley I. F., MacManus D. G., McDonald W. I., Miller D. H. Spinal cord MRI using multi-array coils and fast spin echo. II. Findings in multiple sclerosis. Neurology. 1993 Dec;43(12):2632–2637. doi: 10.1212/wnl.43.12.2632. [DOI] [PubMed] [Google Scholar]
  9. Kurtzke J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–1452. doi: 10.1212/wnl.33.11.1444. [DOI] [PubMed] [Google Scholar]
  10. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  11. Rydberg J. N., Hammond C. A., Grimm R. C., Erickson B. J., Jack C. R., Jr, Huston J., 3rd, Riederer S. J. Initial clinical experience in MR imaging of the brain with a fast fluid-attenuated inversion-recovery pulse sequence. Radiology. 1994 Oct;193(1):173–180. doi: 10.1148/radiology.193.1.8090888. [DOI] [PubMed] [Google Scholar]
  12. Rydberg J. N., Riederer S. J., Rydberg C. H., Jack C. R. Contrast optimization of fluid-attenuated inversion recovery (FLAIR) imaging. Magn Reson Med. 1995 Dec;34(6):868–877. doi: 10.1002/mrm.1910340612. [DOI] [PubMed] [Google Scholar]
  13. Thomas D. J., Pennock J. M., Hajnal J. V., Young I. R., Bydder G. M., Steiner R. E. Magnetic resonance imaging of spinal cord in multiple sclerosis by fluid-attenuated inversion recovery. Lancet. 1993 Mar 6;341(8845):593–594. doi: 10.1016/0140-6736(93)90353-i. [DOI] [PubMed] [Google Scholar]
  14. Thorpe J. W., Kidd D., Kendall B. E., Tofts P. S., Barker G. J., Thompson A. J., MacManus D. G., McDonald W. I., Miller D. H. Spinal cord MRI using multi-array coils and fast spin echo. I. Technical aspects and findings in healthy adults. Neurology. 1993 Dec;43(12):2625–2631. doi: 10.1212/wnl.43.12.2625. [DOI] [PubMed] [Google Scholar]
  15. White S. J., Hajnal J. V., Young I. R., Bydder G. M. Use of fluid-attenuated inversion-recovery pulse sequences for imaging the spinal cord. Magn Reson Med. 1992 Nov;28(1):153–162. doi: 10.1002/mrm.1910280116. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES