Table 2. Compound Exposure Table.
| Treatment
Duration |
Compound | [brain] t, μM | [plasma] t, μM | [brain]
t/
[plasma] t |
|---|---|---|---|---|
| 3 days | Bexarotene
(100 mg/kg) |
6.26 | 5.74 | 1.09 |
| T0901317
(30 mg/kg) |
14.44 | 5.30 | 2.72 | |
| 7 days | Bexarotene
(100 mg/kg) |
3.41 | 4.76 | 0.72 |
| T0901317
(30 mg/kg) |
11.68 | 4.30 | 2.72 |
Following 3 and 7 days of dosing, compound levels were measure in brain homogenate and plasma. Total (t) compound concentrations (μM) are reported in each case. The brain to plasma ratio is also shown (far right-hand column).