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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1997 Feb;62(2):188–192. doi: 10.1136/jnnp.62.2.188

A controlled study of sensory tics in Gilles de 1a Tourette syndrome and obsessive-compulsive disorder using a structured interview.

K Y Chee 1, P Sachdev 1
PMCID: PMC486732  PMID: 9048721

Abstract

OBJECTIVE: To determine the prevalence and characteristics of sensory tics in the Gilles de la Tourette syndrome (GTS), and a matched population of patients with obsessive-compulsive disorder (OCD) using a structured assessment. METHODS: 50 subjects each of GTS, OCD, and healthy controls were studied to determine the prevalence and phenomenology of sensory tics, and diagnose tic disorders, OCD, and affective disorders according to DSM-III-R criteria. The severity of tics and obsessive-compulsive symptoms were quantified using the Tourette syndrome global scale (TSGS) and Yale-Brown obsessive-compulsive scale (Y-BOCS) respectively. RESULTS: The GTS group (28%) had significantly-greater life-time prevalence of sensory tics than the OCD (10%) and healthy (8%) groups (P < 0.05). The sensory tics in both the GTS and OCD groups were predominantly located in rostral anatomical sites. Multiple sensory tics occurred in some patients with GTS or OCD, but not in healthy subjects. Within the OCD group, those who had sensory tics had significantly higher TSGS scores (P < 0.0001), and a higher prevalence of GTS (P < 0.005). CONCLUSIONS: Sensory tics seem to be a common and distinctive feature of GTS and that subpopulation of patients with OCD predisposed to tic disorders. Neurophysiologically, a possible explanation for sensory tics is that they represent the subjectively experienced component of neural dysfunction below the threshold for motor and vocal tic production.

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Selected References

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  1. Apter A., Pauls D. L., Bleich A., Zohar A. H., Kron S., Ratzoni G., Dycian A., Kotler M., Weizman A., Gadot N. An epidemiologic study of Gilles de la Tourette's syndrome in Israel. Arch Gen Psychiatry. 1993 Sep;50(9):734–738. doi: 10.1001/archpsyc.1993.01820210068008. [DOI] [PubMed] [Google Scholar]
  2. Bliss J. Sensory experiences of Gilles de la Tourette syndrome. Arch Gen Psychiatry. 1980 Dec;37(12):1343–1347. doi: 10.1001/archpsyc.1980.01780250029002. [DOI] [PubMed] [Google Scholar]
  3. Chase T. N., Geoffrey V., Gillespie M., Burrows G. H. Structural and functional studies of Gilles de la Tourette syndrome. Rev Neurol (Paris) 1986;142(11):851–855. [PubMed] [Google Scholar]
  4. Cohen A. J., Leckman J. F. Sensory phenomena associated with Gilles de la Tourette's syndrome. J Clin Psychiatry. 1992 Sep;53(9):319–323. [PubMed] [Google Scholar]
  5. Frankel M., Cummings J. L., Robertson M. M., Trimble M. R., Hill M. A., Benson D. F. Obsessions and compulsions in Gilles de la Tourette's syndrome. Neurology. 1986 Mar;36(3):378–382. doi: 10.1212/wnl.36.3.378. [DOI] [PubMed] [Google Scholar]
  6. Fried I., Katz A., McCarthy G., Sass K. J., Williamson P., Spencer S. S., Spencer D. D. Functional organization of human supplementary motor cortex studied by electrical stimulation. J Neurosci. 1991 Nov;11(11):3656–3666. doi: 10.1523/JNEUROSCI.11-11-03656.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. George M. S., Trimble M. R., Costa D. C., Robertson M. M., Ring H. A., Ell P. J. Elevated frontal cerebral blood flow in Gilles de la Tourette syndrome: a 99Tcm-HMPAO SPECT study. Psychiatry Res. 1992 Nov;45(3):143–151. doi: 10.1016/0925-4927(92)90022-v. [DOI] [PubMed] [Google Scholar]
  8. Goodman W. K., Price L. H., Rasmussen S. A., Mazure C., Delgado P., Heninger G. R., Charney D. S. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry. 1989 Nov;46(11):1012–1016. doi: 10.1001/archpsyc.1989.01810110054008. [DOI] [PubMed] [Google Scholar]
  9. Goodman W. K., Price L. H., Rasmussen S. A., Mazure C., Fleischmann R. L., Hill C. L., Heninger G. R., Charney D. S. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989 Nov;46(11):1006–1011. doi: 10.1001/archpsyc.1989.01810110048007. [DOI] [PubMed] [Google Scholar]
  10. Grad L. R., Pelcovitz D., Olson M., Matthews M., Grad G. J. Obsessive-compulsive symptomatology in children with Tourette's syndrome. J Am Acad Child Adolesc Psychiatry. 1987 Jan;26(1):69–73. doi: 10.1097/00004583-198701000-00014. [DOI] [PubMed] [Google Scholar]
  11. Harcherik D. F., Leckman J. F., Detlor J., Cohen D. J. A new instrument for clinical studies of Tourette's syndrome. J Am Acad Child Psychiatry. 1984 Mar;23(2):153–160. doi: 10.1097/00004583-198403000-00006. [DOI] [PubMed] [Google Scholar]
  12. Hoover J. E., Strick P. L. Multiple output channels in the basal ganglia. Science. 1993 Feb 5;259(5096):819–821. doi: 10.1126/science.7679223. [DOI] [PubMed] [Google Scholar]
  13. Kurlan R., Lichter D., Hewitt D. Sensory tics in Tourette's syndrome. Neurology. 1989 May;39(5):731–734. doi: 10.1212/wnl.39.5.731. [DOI] [PubMed] [Google Scholar]
  14. Leckman J. F., Walker D. E., Cohen D. J. Premonitory urges in Tourette's syndrome. Am J Psychiatry. 1993 Jan;150(1):98–102. doi: 10.1176/ajp.150.1.98. [DOI] [PubMed] [Google Scholar]
  15. Lees A. J., Robertson M., Trimble M. R., Murray N. M. A clinical study of Gilles de la Tourette syndrome in the United Kingdom. J Neurol Neurosurg Psychiatry. 1984 Jan;47(1):1–8. doi: 10.1136/jnnp.47.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Leonard H. L., Lenane M. C., Swedo S. E., Rettew D. C., Gershon E. S., Rapoport J. L. Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children. Am J Psychiatry. 1992 Sep;149(9):1244–1251. doi: 10.1176/ajp.149.9.1244. [DOI] [PubMed] [Google Scholar]
  18. Pauls D. L., Towbin K. E., Leckman J. F., Zahner G. E., Cohen D. J. Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship. Arch Gen Psychiatry. 1986 Dec;43(12):1180–1182. doi: 10.1001/archpsyc.1986.01800120066013. [DOI] [PubMed] [Google Scholar]
  19. Peterson B., Riddle M. A., Cohen D. J., Katz L. D., Smith J. C., Hardin M. T., Leckman J. F. Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images. Neurology. 1993 May;43(5):941–949. doi: 10.1212/wnl.43.5.941. [DOI] [PubMed] [Google Scholar]
  20. Robertson M. M., Channon S., Baker J., Flynn D. The psychopathology of Gilles de la Tourette's syndrome. A controlled study. Br J Psychiatry. 1993 Jan;162:114–117. doi: 10.1192/bjp.162.1.114. [DOI] [PubMed] [Google Scholar]
  21. Romo R., Scarnati E., Schultz W. Role of primate basal ganglia and frontal cortex in the internal generation of movements. II. Movement-related activity in the anterior striatum. Exp Brain Res. 1992;91(3):385–395. doi: 10.1007/BF00227835. [DOI] [PubMed] [Google Scholar]
  22. Romo R., Schultz W. Role of primate basal ganglia and frontal cortex in the internal generation of movements. III. Neuronal activity in the supplementary motor area. Exp Brain Res. 1992;91(3):396–407. doi: 10.1007/BF00227836. [DOI] [PubMed] [Google Scholar]
  23. Schultz W., Romo R. Role of primate basal ganglia and frontal cortex in the internal generation of movements. I. Preparatory activity in the anterior striatum. Exp Brain Res. 1992;91(3):363–384. doi: 10.1007/BF00227834. [DOI] [PubMed] [Google Scholar]
  24. Singer H. S., Reiss A. L., Brown J. E., Aylward E. H., Shih B., Chee E., Harris E. L., Reader M. J., Chase G. A., Bryan R. N. Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. Neurology. 1993 May;43(5):950–956. doi: 10.1212/wnl.43.5.950. [DOI] [PubMed] [Google Scholar]
  25. Van Buren J. M., Fedio P. Functional representation on the medial aspect of the frontal lobes in man. J Neurosurg. 1976 Mar;44(3):275–289. doi: 10.3171/jns.1976.44.3.0275. [DOI] [PubMed] [Google Scholar]

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