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. 1992 Mar 15;89(6):2444–2447. doi: 10.1073/pnas.89.6.2444

Cloning of a D-type cyclin from murine erythroleukemia cells.

H Kiyokawa 1, X Busquets 1, C T Powell 1, L Ngo 1, R A Rifkind 1, P A Marks 1
PMCID: PMC48674  PMID: 1372445

Abstract

We report the complete coding sequence of a cDNA, designated CYL2, derived from a murine erythroleukemia cell library. CYL2 is considered to encode a D-type cyclin because (i) there is cross hybridization with CYL1 (a murine homolog of human cyclin D1) and the encoded protein has 64% amino acid sequence identity with CYL1 and (ii) murine erythroleukemia cell-derived CYL2 contains an amino acid sequence identical to that previously reported for the C-terminal portion of a partially sequenced CYL2. Transcripts of murine erythroleukemia cell CYL2 undergo alternative polyadenylylation like that of human cyclin D1. A major 6.5-kilobase CYL2 transcript changes its expression during the cell cycle with a broad peak through G1 and S phases and a decrease in G2/M phases. The present findings suggest that CYL2 plays a role in the G1 to S phase progression.

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Selected References

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