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. 1979 Feb;41(2):167–174. doi: 10.1136/hrt.41.2.167

Management of unstable angina at rest by verapamil. A double-blind cross-over study in coronary care unit.

O Parodi, A Maseri, I Simonetti
PMCID: PMC486844  PMID: 371644

Abstract

A therapeutic trial with verapamil, a calcium-antagonist drug, was performed in 12 patients admitted to our coronary care unit because of frequent daily attacks of angina at rest attributed to coronary vasospasm. After a 48-hour run-in period, oral verapamil 480 mg/day and placebo were administered alternately during 4 randomised 48-hour periods. Transient ischaemic attacks with ST segment elevation or depression, with or without pain, were documented by continuous electrocardiographic monitoring. The number of attacks during the run-in and 2 placebo periods were 128, 123, and 130, respectively, and 31 and 23 during the 2 treatment periods (P less than 0.006 and P less than 0.003). This drug therefore appears to be effective in the management of patients with frequent attacks of angina at rest.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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