Abstract
Peak and mean left ventricular ejection power were measured during atrial pacing in 6 normal subjects (group I), 6 patients with coronary artery disease without myocardial infarction (group IIa), and 10 patients with coronary artery disease after myocardial infarction (group IIb). Pacing rates were 80 and 120/min. Power was determined by computer analysis of pressure, volume, and time. Data were normalised by end-diastolic volume and left ventricular muscle mass. Peak left ventricular ejection power normalised by end-diastolic volume values at a pacing rate of 120 min were significantly lower in group IIa and IIb than in normal subjects. Mean muscle mass in normal subjects was 179 g and in group IIa 216 g (P smaller than 0.05). Peak power normalised by muscle mass in normal subjects tended to increase at 120/min whereas in group IIa it declined by 26 per cent (P less than 0.001). These data indicate that the energy output of the left ventricle at rest may be the same in patients with significant coronary artery disease as in normal subjects. Increasing the heart rate from 80 to 120/min in a normal myocardium augments power but in coronary artery disease it remains static or falls.
Full text
PDF






Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brutsaert D. L., Sonnenblick E. H. Cardiac muscle mechanics in the evaluation of myocardial contractility and pump function: problems, concepts, and directions. Prog Cardiovasc Dis. 1973 Nov-Dec;16(3):337–361. doi: 10.1016/s0033-0620(73)80005-2. [DOI] [PubMed] [Google Scholar]
- CHAPMAN C. B., BAKER O., MITCHELL J. H. Left ventricular function at rest and during exercise. J Clin Invest. 1959 Jul;38(7):1202–1213. doi: 10.1172/JCI103895. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dwyer E. M., Jr Left ventricular pressure-volume alterations and regional disorders of contraction during myocardial ischemia induced by atrial pacing. Circulation. 1970 Dec;42(6):1111–1122. doi: 10.1161/01.cir.42.6.1111. [DOI] [PubMed] [Google Scholar]
- Forrester J. S., Helfant R. H., Pasternac A., Amsterdam E. A., Most A. S., Kemp H. G., Gorlin R. Atrial pacing in coronary heart disease. Effect on hemodynamics, metabolism and coronary circulation. Am J Cardiol. 1971 Mar;27(3):237–243. doi: 10.1016/0002-9149(71)90296-7. [DOI] [PubMed] [Google Scholar]
- Greenfield J. C., Jr, Harley A., Thompson H. K., Wallace A. G. Pressure-flow studies in man during atrial fibrillation. J Clin Invest. 1968 Oct;47(10):2411–2421. doi: 10.1172/JCI105924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HERNANDEZ R. R., GREENFIELD J. C., Jr, MCCALL B. W. PRESSURE-FLOW STUDIES IN HYPERTROPHIC SUBAORTIC STENOSIS. J Clin Invest. 1964 Mar;43:401–407. doi: 10.1172/JCI104924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hagemann K., Meyer J. Kontrastmitteldarstellung des linken Ventrikels nach Injektion in den rechten Vorhof. Klin Wochenschr. 1978 Apr 1;56(7):351–354. doi: 10.1007/BF01477395. [DOI] [PubMed] [Google Scholar]
- Jensch P., Meyer J., Mattar E., Ameling W., Effert S. Ein Prozessrechnersystem für Herzkatheterlabor und Hämodynamikmessplätze. Z Kardiol. 1976 Oct;65(10):850–881. [PubMed] [Google Scholar]
- RACKLEY C. E., DODGE H. T., COBLE Y. D., Jr, HAY R. E. A METHOD FOR DETERMINING LEFT VENTRICULAR MASS IN MAN. Circulation. 1964 May;29:666–671. doi: 10.1161/01.cir.29.5.666. [DOI] [PubMed] [Google Scholar]
- Russell R. O., Jr, Porter C. M., Frimer M., Dodge H. T. Left ventricular power in man. Am Heart J. 1971 Jun;81(6):799–808. doi: 10.1016/0002-8703(71)90084-6. [DOI] [PubMed] [Google Scholar]
- SNELL R. E., LUCHSINGER P. C. DETERMINATION OF THE EXTERNAL WORK AND POWER OF THE LEFT VENTRICLE IN INTACT MAN. Am Heart J. 1965 Apr;69:529–537. doi: 10.1016/0002-8703(65)90424-2. [DOI] [PubMed] [Google Scholar]
- Sonnenblick E. H., Strobeck J. E. Current concepts in cardiology. Derived indexes of ventricular and myocardial function. N Engl J Med. 1977 Apr 28;296(17):978–982. doi: 10.1056/NEJM197704282961706. [DOI] [PubMed] [Google Scholar]
- Stein P. D., Sabbah H. N. Rate of change of ventricular power: an indicator of ventricular performance during ejection. Am Heart J. 1976 Feb;91(2):219–227. doi: 10.1016/s0002-8703(76)80577-7. [DOI] [PubMed] [Google Scholar]
- Stein P. D., Sabbah H. N. Ventricular performance measured during ejection: Studies in patients of the rate of change of ventricular power. Am Heart J. 1976 May;91(5):599–606. doi: 10.1016/s0002-8703(76)80145-7. [DOI] [PubMed] [Google Scholar]
