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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Anesthesiology. 2016 Jun;124(6):1311–1327. doi: 10.1097/ALN.0000000000001111

Figure 6. The global HDAC inhibitor sodium butyrate reverses general anesthesia (GA)-induced histone-3 hypoacetylation in the immature hippocampus.

Figure 6

Sodium butyrate (NaB) (at 1.2 g/kg, i.p.) was given 60 minutes before the tissue collection. (A) The GA-induced H3 hypoacetylation (****, p=0.0001; n=6) is not only completely reversed, but there is a significant increase in acetylated H3 as compared with sham controls (*, p=0.019; n=6). NaB alone, at this dose, also caused upregulation of acetylated H3 as compared with sham controls (****, p=0.0001; n=6 rat pups per data point). (B) NaB also reversed the GA-induced decrease in acetylated H3 at 24 h (***, p=001; n=6), and also resulted in significant increase in acetylated H3 compared with sham controls (**, p=0.004; n=6). Again, NaB alone caused an increase in acetylated H3 as compared with sham controls (**, p=0.009; n=6).