Figure 1.

HFD-induced glucose intolerance and insulin resistance are attenuated in S1pr2^−/− mice. Ten-week-old WT and S1pr2^−/− male mice were fed a HFD for 4 weeks. A, Body weight changes after feeding a normal diet. B, Body weight changes after feeding a HFD. C, Fasting plasma glucose levels in normal diet- and HFD-fed WT and S1pr2^−/− mice. D, ip-GTT in normal diet-fed WT and S1pr2^−/− mice. E, ip-GTT in HFD-fed WT and S1pr2^−/− mice. F, ip-ITT in HFD-fed WT and S1pr2^−/− mice. In D–F, the AUCs are shown as inset graphs. Data are mean ± SEM (n, sample numbers); *, P < .05 and **, P < .01 vs WT samples; and #, P < .05 vs normal diet-fed samples (t test).