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Increase of intracellular cAMP by FSK decreases nonstimulated ALPL levels, whereas H-89 and Gαs knockdown markedly increase it. U2OS-TSHR cells were treated with 10μM FSK or H-89. GNAS siRNA was used to knockdown Gαs. After 5 days, levels of ALPL expression were determined by RT-qPCR. The data are from 3 independent experiments with duplicate samples, and are presented as the mean ± SEM.
