Recently, our partner journal Archives of Toxicology published a special issue addressing the key questions in nanotoxicology (Weiss and Diabaté, 2011[12]). The number of commercially available nanomaterials is rapidly growing. Thus, one aspect of nanotoxicology is the unintended exposure to nanomaterials. Pharmaceutical nanoproducts have been introduced for diagnostics, drug delivery or cancer treatment, and scientists in the field of toxicology are expected to identify and prevent side effects arising from these uses. To provide our readers with an overview of the latest topics in the field of nanotoxicology, we summarize the key messages of the recent special issue (Table 1(Tab. 1)). (References in Table 1: Bolt et al., 2012[2]; Hoshino et al., 2011[7]; Clift et al., 2011[3]; Marano et al., 2011[10]; Foldbjerg et al., 2011[4]; Gibson et al., 2011[6]; Kim et al., 2011[8]; Truong et al., 2011[11]; Gehrke et al., 2011[5]; Al-Rawi et al., 2011[1]; Leppänen et al., 2011[9])
Table 1. Recent developments in nanotoxicology (from: Bolt et al., 2012).
References
- 1.Al-Rawi M, Diabaté S, Weiss C. Uptake and intracellular localization of submicron and nano-sized SiO₂ particles in HeLa cells. Arch Toxicol. 2011;85(7):813–826. doi: 10.1007/s00204-010-0642-5. [DOI] [PubMed] [Google Scholar]
- 2.Bolt HM, Marchan R, Hengstler JG. Recent developments in nanotoxicology. Arch Toxicol. 2012:ahead of print. doi: 10.1007/s00204-012-0851-1. [DOI] [PubMed] [Google Scholar]
- 3.Clift MJD, Gehr P, Rothen-Rutishauser B. Nanotoxicology: a persepective and discussion of whether or not in vitro testing is a valid alternative. Arch Toxicol. 2011;85:723–731. doi: 10.1007/s00204-010-0560-6. [DOI] [PubMed] [Google Scholar]
- 4.Foldbjerg R, Dang DA, Autrup H. Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol. 2011;85:743–750. doi: 10.1007/s00204-010-0545-5. [DOI] [PubMed] [Google Scholar]
- 5.Gehrke H, Pelka J, Hartinger CG, Blank H, Bleimund F, Schneider R, et al. Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations. Arch Toxicol. 2011;85:799–812. doi: 10.1007/s00204-010-0636-3. [DOI] [PubMed] [Google Scholar]
- 6.Gibson N, Holzwarth U, Abbas K, Simonelli F, Kozempel J, Cydzik I, et al. Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators. Arch Toxicol. 2011;85:751–773. doi: 10.1007/s00204-011-0701-6. [DOI] [PubMed] [Google Scholar]
- 7.Hoshino A, Hanada S, Yamamoto K. Toxicity of nanocrystal quantum dots: the relevance of surface modifications. Arch Toxicol. 2011;85:707–720. doi: 10.1007/s00204-011-0695-0. [DOI] [PubMed] [Google Scholar]
- 8.Kim JS, Lee K, Lee YH, Cho HS, Kim KH, Choi KH, et al. Aspect ratio has no effect on genotoxicity of multi-wall carbon nanotubes. Arch Toxicol. 2011;85:775–786. doi: 10.1007/s00204-010-0574-0. [DOI] [PubMed] [Google Scholar]
- 9.Leppänen M, Korpi A, Miettinen M, Leskinen J, Torvela T, Rossi EM, et al. Nanosized TiO₂ caused minor airflow limitation in the murine airways. Arch Toxicol. 2011;85:827–839. doi: 10.1007/s00204-011-0644-y. [DOI] [PubMed] [Google Scholar]
- 10.Marano F, Hussain S, Rodrigues-Lima F, Baeza-Squiban A, Boland S. Nanoparticles: molecular targets and cell signalling. Arch Toxicol. 2011;85:733–741. doi: 10.1007/s00204-010-0546-4. [DOI] [PubMed] [Google Scholar]
- 11.Truong L, Moody IS, Stankus DP, Nason JA, Lonergan MC, Tanguay RL. Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish. Arch Toxicol. 2011;85:787–798. doi: 10.1007/s00204-010-0627-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Weiss C, Diabaté S. A special issue on nanotoxicology. Arch Toxicol. 2011;85:705–706. doi: 10.1007/s00204-011-0707-0. [DOI] [PubMed] [Google Scholar]