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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Hepatology. 2016 Mar 25;63(6):1900–1913. doi: 10.1002/hep.28508

Figure 6.

Figure 6

Inhibition of HCC but not ICC development in FASNfl/fl mice injected with activated forms of AKT and Ras. (A) Study design: activated forms of AKT and NRas (N-RasV12) were hydrodynamically injected together with Cre into FASNfl/fl mice (AKT/Ras/Cre). As control, AKT and NRasV12 were injected in the same mice together with the empty vector (AKT/Ras/pT3). (B) Survival curve of AKT/Ras/Cre (n=5) and AKT/Ras/pT3 mice (n=5). (C) Microscopically, AKT/Ras/pT3 livers consisted mostly of lipid-rich, hepatocellular lesions with few CK19(+) cholangiocellular lesions. In striking contrast, deletion of FASN by the Cre system resulted in the almost complete disappearance of hepatocellular lesions but the expansion of cholangiocellular CK(+) lesions in AKT/Ras/Cre mice. Original magnification: 40X. Abbreviation: HE, hematoxylin and eosin staining.