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. 2010 Feb 6;1(2):109–114. doi: 10.1007/s13238-010-0029-7

Bat and virus

Zhengli Shi 1,✉
PMCID: PMC4875169  PMID: 21203979

Abstract

Bat, the only flying mammal and count more than 20% of the extant mammals on earth, were recently identified as a natural reservoir of emerging and reemerging infectious pathogens. Astonishing amount (more than 70) and genetic diversity of viruses isolated from the bat have been identified in different populations throughout the world. Many studies focus on bat viruses that caused severe domestic and human diseases. However, many viruses were found in apparently healthy bats, suggesting that bats may have a specific immune system or antiviral activity against virus infections. Therefore, basic researches for bat immunology and virus-host interactions are important for understanding bat-derived infectious diseases.

References

  1. Aguirre L.F., Herrel A., Van Damme R., Matthysen E. The implications of food hardness for diet in bats. Functional Ecology. 2003;17:201–212. doi: 10.1046/j.1365-2435.2003.00721.x. [DOI] [Google Scholar]
  2. Almeida M.F., Martorelli L.F., Aires C.C., Sallum P.C., Durigon E.L., Massad E. Experimental rabies infection in haematophagous bats Desmodus rotundus. Epidemiol Infect. 2005;133:523–527. doi: 10.1017/S0950268804003656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Badilla X., Perez-Herra V., Quiros L., Morice A., Jimenez E., Saenz E., Salazar F., Fernandez R., Orciari L., Yager P., et al. Human rabies: a reemerging disease in Costa Rica? Emerg Infect Dis. 2003;9:721–723. doi: 10.3201/eid0906.020632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Badrane H., Tordo N. Host switching in Lyssavirus history from the Chiroptera to the Carnivora orders. J Virol. 2001;75:8096–8104. doi: 10.1128/JVI.75.17.8096-8104.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Biek R., Walsh P.D., Leroy E.M., Real L.A. Recent common ancestry of Ebola Zaire virus found in a bat reservoir. PLoS Pathog. 2006;2:e90. doi: 10.1371/journal.ppat.0020090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Blanton J.D., Palmer D., Christian K.A., Rupprecht C.E. Rabies surveillance in the United States during 2007. J Am Vet Med Assoc. 2008;233:884–897. doi: 10.2460/javma.233.6.884. [DOI] [PubMed] [Google Scholar]
  7. Bourhy H., Kissi B., Tordo N. Molecular diversity of the Lyssavirus genus. Virology. 1993;194:70–81. doi: 10.1006/viro.1993.1236. [DOI] [PubMed] [Google Scholar]
  8. Calisher C.H., Childs J.E., Field H.E., Holmes K.V., Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev. 2006;19:531–545. doi: 10.1128/CMR.00017-06. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Carrington C.V., Foster J.E., Zhu H.C., Zhang J.X., Smith G.J., Thompson N., Auguste A.J., Ramkissoon V., Adesiyun A.A., Guan Y. Detection and phylogenetic analysis of group 1 coronaviruses in South American bats. Emerg Infect Dis. 2008;14:1890–1893. doi: 10.3201/eid1412.080642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Chadha M.S., Comer J.A., Lowe L., Rota P.A., Rollin P.E., Bellini W.J., Ksiazek T.G., Mishra A. Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis. 2006;12:235–240. doi: 10.3201/eid1202.051247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Chan-Yeung M., Xu R.H. SARS: epidemiology. Respirology. 2003;8(Suppl):S9–14. doi: 10.1046/j.1440-1843.2003.00518.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Chu D.K., Poon L.L., Chan K.H., Chen H., Guan Y., Yuen K.Y., Peiris J.S. Coronaviruses in bent-winged bats (Miniopterus spp.) J Gen Virol. 2006;87:2461–2466. doi: 10.1099/vir.0.82203-0. [DOI] [PubMed] [Google Scholar]
  13. Chu D.K., Poon L.L., Guan Y., Peiris J.S. Novel astroviruses in insectivorous bats. J Virol. 2008;82:9107–9114. doi: 10.1128/JVI.00857-08. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Chua K.B., Bellini W.J., Rota P.A., Harcourt B.H., Tamin A., Lam S.K., Ksiazek T.G., Rollin P.E., Zaki S.R., Shieh W., et al. Nipah virus: a recently emergent deadly paramyxovirus. Science. 2000;288:1432–1435. doi: 10.1126/science.288.5470.1432. [DOI] [PubMed] [Google Scholar]
  15. Chua K.B., Crameri G., Hyatt A., Yu M., Tompang M.R., Rosli J., McEachern J., Crameri S., Kumarasamy V., Eaton B.T., et al. A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans. Proc Natl Acad Sci U S A. 2007;104:11424–11429. doi: 10.1073/pnas.0701372104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Chua K.B., Koh C.L., Hooi P.S., Wee K.F., Khong J.H., Chua B.H., Chan Y.P., Lim M.E., Lam S.K. Isolation of Nipah virus from Malaysian Island flying-foxes. Microbes Infect. 2002;4:145–151. doi: 10.1016/S1286-4579(01)01522-2. [DOI] [PubMed] [Google Scholar]
  17. Dominguez S.R., O’shea T.J., Oko L.M., Holmes K.V. Detection of group 1 coronaviruses in bats in North America. Emerg Infect Dis. 2007;13:1295–1300. doi: 10.3201/eid1309.070491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Eaton B.T., Broder C.C., Middleton D., Wang L.F. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol. 2006;4:23–35. doi: 10.1038/nrmicro1323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Eaton B.T., Mackenzie J.S., Wang L.F. Henipaviruses. In: Knipe D.M., Griffin D.E., Lamb R.A., Straus S.E., Howley P.M., Martin M.A., Roizman B., editors. Fields Virology. 5 edn. Philadelphia, USA: Higher Education Press and Springer-Verlag; 2007. pp. 1587–1600. [Google Scholar]
  20. Emond R.T., Evans B., Bowen E.T., Lloyd G. A case of Ebola virus infection. Br Med J. 1977;2:541–544. doi: 10.1136/bmj.2.6086.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Favi M., de Mattos C.A., Yung V., Chala E., Lopez L.R., de Mattos C.C. First case of human rabies in chile caused by an insectivorous bat virus variant. Emerg Infect Dis. 2002;8:79–81. doi: 10.3201/eid0801.010108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Field H. Hendra re-visited. Virologica Sinica. 2008;24:105–109. doi: 10.1007/s12250-009-3034-3. [DOI] [Google Scholar]
  23. Fooks A.R., McElhinney L.M., Pounder D.J., Finnegan C.J., Mansfield K., Johnson N., Brookes S.M., Parsons G., White K., McIntyre P.G., et al. Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitis. J Med Virol. 2003;71:281–289. doi: 10.1002/jmv.10481. [DOI] [PubMed] [Google Scholar]
  24. Gloza-Rausch F., Ipsen A., Seebens A., Gottsche M., Panning M., Felix Drexler J., Petersen N., Annan A., Grywna K., Muller M., et al. Detection and prevalence patterns of group I corona-viruses in bats, northern Germany. Emerg Infect Dis. 2008;14:626–631. doi: 10.3201/eid1404.071439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Gonzalez J.P., Pourrut X., Leroy E. Ebolavirus and other filoviruses. Curr Top Microbiol Immunol. 2007;315:363–387. doi: 10.1007/978-3-540-70962-6_15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Halpin K., Young P.L., Field H., Mackenzie J.S. Newly discovered viruses of flying foxes. Vet Microbiol. 1999;68:83–87. doi: 10.1016/S0378-1135(99)00063-2. [DOI] [PubMed] [Google Scholar]
  27. Hanna J.N., Carney I.K., Smith G.A., Tannenberg A.E., Deverill J. E., Botha J.A., Serafin I.L., Harrower B.J., Fitzpatrick P.F., Searle J.W. Australian bat lyssavirus infection: a second human case, with a long incubation period. Med J Aust. 2000;172:597–599. doi: 10.5694/j.1326-5377.2000.tb124126.x. [DOI] [PubMed] [Google Scholar]
  28. Hon C.C., Lam T.Y., Shi Z.L., Drummond A.J., Yip C.W., Zeng F., Lam P.Y., Leung F.C. Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus. J Virol. 2008;82:1819–1826. doi: 10.1128/JVI.01926-07. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hughes G.J., Kuzmin I.V., Schmitz A., Blanton J., Manangan J., Murphy S., Rupprecht C.E. Experimental infection of big brown bats (Eptesicus fuscus) with Eurasian bat lyssaviruses Aravan, Khujand, and Irkut virus. Arch Virol. 2006;151:2021–2035. doi: 10.1007/s00705-005-0785-0. [DOI] [PubMed] [Google Scholar]
  30. Jones K.E., Patel N.G., Levy M.A., Storeygard A., Balk D., Gittleman J.L., Daszak P. Global trends in emerging infectious diseases. Nature. 2008;451:990–993. doi: 10.1038/nature06536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Lau S.K., Woo P.C., Li K.S., Huang Y., Tsoi H.W., Wong B.H., Wong S.S., Leung S.Y., Chan K.H., Yuen K.Y. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci U S A. 2005;102:14040–14045. doi: 10.1073/pnas.0506735102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Lau S.K., Woo P.C., Li K.S., Huang Y., Wang M., Lam C.S., Xu H., Guo R., Chan K.H., Zheng B.J., Yuen K.Y. Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome. Virology. 2007;367:428–439. doi: 10.1016/j.virol.2007.06.009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Lehle C., Razafitrimo G., Razainirina J., Andriaholinirina N., Goodman S.M., Faure C., Georges-Courbot M.C., Rousset D., Reynes J.M. Henipavirus and Tioman virus antibodies in pteropodid bats, Madagascar. Emerg Infect Dis. 2007;13:159–161. doi: 10.3201/eid1301.060791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Leroy E.M., Kumulungui B., Pourrut X., Rouquet P., Hassanin A., Yaba P., Delicat A., Paweska J.T., Gonzalez J.P., Swanepoel R. Fruit bats as reservoirs of Ebola virus. Nature. 2005;438:575–576. doi: 10.1038/438575a. [DOI] [PubMed] [Google Scholar]
  35. Li W., Zhang C., Sui J., Kuhn J.H., Moore M.J., Luo S., Wong S. K., Huang I.C., Xu K., Vasilieva N., et al. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J. 2005;24:1634–1643. doi: 10.1038/sj.emboj.7600640. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Li Y., Wang J., Hickey A.C., Zhang Y., Wu Y., Zhang H., Yuan J., Han Z., McEachern J., Broder C.C., Wang L.F., Shi Z. Antibodies to Nipah or Nipah-like viruses in bats, China. Emerg Infect Dis. 2008;14:1974–1976. doi: 10.3201/eid1412.080359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Malherbe H., Strickland-Cholmley M. Human disease from monkeys (Marburg virus) Lancet. 1968;1:1434. doi: 10.1016/S0140-6736(68)92023-0. [DOI] [PubMed] [Google Scholar]
  38. Middleton D.J., Morrissy C.J., van der Heide B.M., Russell G.M., Braun M.A., Westbury H.A., Halpin K., Daniels P.W. Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus) J Comp Pathol. 2007;136:266–272. doi: 10.1016/j.jcpa.2007.03.002. [DOI] [PubMed] [Google Scholar]
  39. Misra V., Dumonceaux T., Dubois J., Willis C., Nadin-Davis S., Severini A., Wandeler A., Lindsay R., Artsob H. Detection of polyoma and corona viruses in bats of Canada. J Gen Virol. 2009;90:2015–2022. doi: 10.1099/vir.0.010694-0. [DOI] [PubMed] [Google Scholar]
  40. Molnar V., Janoska M., Harrach B., Glavits R., Palmai N., Rigo D., Sos E., Liptovszky M. Detection of a novel bat gammaherpesvirus in Hungary. Acta Vet Hung. 2008;56:529–538. doi: 10.1556/AVet.56.2008.4.10. [DOI] [PubMed] [Google Scholar]
  41. Muller M.A., Paweska J.T., Leman P.A., Drosten C., Grywna K., Kemp A., Braack L., Sonnenberg K., Niedrig M., Swanepoel R. Coronavirus antibodies in African bat species. Emerg Infect Dis. 2007;13:1367–1370. doi: 10.3201/eid1309.070342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Murray K., Selleck P., Hooper P., Hyatt A., Gould A., Gleeson L., Westbury H., Hiley L., Selvey L., Rodwell B., et al. A morbillivirus that caused fatal disease in horses and humans. Science. 1995;268:94–97. doi: 10.1126/science.7701348. [DOI] [PubMed] [Google Scholar]
  43. Nathwani D., McIntyre P.G., White K., Shearer A.J., Reynolds N., Walker D., Orange G.V., Fooks A.R. Fatal human rabies caused by European bat Lyssavirus type 2a infection in Scotland. Clin Infect Dis. 2003;37:598–601. doi: 10.1086/376641. [DOI] [PubMed] [Google Scholar]
  44. Paton N.I., Leo Y.S., Zaki S.R., Auchus A.P., Lee K.E., Ling A.E., Chew S.K., Ang B., Rollin P.E., Umapathi T., et al. Outbreak of Nipah-virus infection among abattoir workers in Singapore. Lancet. 1999;354:1253–1256. doi: 10.1016/S0140-6736(99)04379-2. [DOI] [PubMed] [Google Scholar]
  45. Patterson B.D., Willig M.R., Stevens R.D. Trophic strategies, niche partitioning, and patterns of ecological organization. In: IKunz T.H., Fenton M.B., editors. Bat Ecology. Chicago: The University of Chicago Press; 2003. pp. 536–579. [Google Scholar]
  46. Paweska J.T., Blumberg L.H., Liebenberg C., Hewlett R.H., Grobbelaar A.A., Leman P.A., Croft J.E., Nel L.H., Nutt L., Swanepoel R. Fatal human infection with rabies-related Duvenhage virus, South Africa. Emerg Infect Dis. 2006;12:1965–1967. doi: 10.3201/eid1212.060764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Pfefferle S., Oppong S., Drexler J.F., Gloza-Rausch F., Ipsen A., Seebens A., Muller M.A., Annan A., Vallo P., Adu-Sarkodie Y., et al. Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana. Emerg Infect Dis. 2009;15:1377–1384. doi: 10.3201/eid1509.090224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Poon L.L., Chu D.K., Chan K.H., Wong O.K., Ellis T.M., Leung Y. H., Lau S.K., Woo P.C., Suen K.Y., Yuen K.Y., et al. Identification of a novel coronavirus in bats. J Virol. 2005;79:2001–2009. doi: 10.1128/JVI.79.4.2001-2009.2005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Pourrut X., Delicat A., Rollin P.E., Ksiazek T.G., Gonzalez J.P., Leroy E.M. Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species. J Infect Dis. 2007;196(Suppl2):S176–183. doi: 10.1086/520541. [DOI] [PubMed] [Google Scholar]
  50. Pourrut X., Souris M., Towner J.S., Rollin P.E., Nichol S.T., Gonzalez J.P., Leroy E. Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus. BMC Infect Dis. 2009;9:159. doi: 10.1186/1471-2334-9-159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Razafindratsimandresy R., Jeanmaire E.M., Counor D., Vasconcelos P.F., Sall A.A., Reynes J.M. Partial molecular characterization of alphaherpesviruses isolated from tropical bats. J Gen Virol. 2009;90:44–47. doi: 10.1099/vir.0.006825-0. [DOI] [PubMed] [Google Scholar]
  52. Ren W., Li W., Yu M., Hao P., Zhang Y., Zhou P., Zhang S., Zhao G., Zhong Y., Wang S., et al. Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis. J Gen Virol. 2006;87:3355–3359. doi: 10.1099/vir.0.82220-0. [DOI] [PubMed] [Google Scholar]
  53. Ren W., Qu X., Li W., Han Z., Yu M., Zhou P., Zhang S.Y., Wang L.F., Deng H., Shi Z. Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J Virol. 2008;82:1899–1907. doi: 10.1128/JVI.01085-07. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Reynes J.M., Counor D., Ong S., Faure C., Seng V., Molia S., Walston J., Georges-Courbot M.C., Deubel V., Sarthou J.L. Nipah virus in Lyle’s flying foxes, Cambodia. Emerg Infect Dis. 2005;11:1042–1047. doi: 10.3201/eid1107.041350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Sanchez A., Geisbert T.W., Feldmann H. Filoviridae: Marburg and Ebola viruses. In: Knipe H.P., editor. fields virology. Philidelphia: Lippincott Williams and Williams; 2007. pp. 1409–1448. [Google Scholar]
  56. Sendow I., Field H.E., Curran J., Darminto, Morrissy C., Meehan G., Buick T., Daniels P. Henipavirus in Pteropus vampyrus bats, Indonesia. Emerg Infect Dis. 2006;12:711–712. doi: 10.3201/eid1204.051181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Simmons N.B. Order Chiroptera. In: Wilson D.E., Reeder D.M., editors. Mammal species of the world: a taxonomic and geographic reference. 3 edn. Baltimore: John Hopkins University Press; 2005. pp. 312–529. [Google Scholar]
  58. Sonntag M., Muhldorfer K., Speck S., Wibbelt G., Kurth A. New adenovirus in bats, Germany. Emerg Infect Dis. 2009;15:2052–2055. doi: 10.3201/eid1512.090646. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Sulkin S., Sulkin E., Allen R. Virus infction in bats. In: Melnick J.L., editor. Monographs in Virology. Houston: S · KargerAG, Basel; 1974. [Google Scholar]
  60. Swanepoel R., Smit S.B., Rollin P.E., Formenty P., Leman P.A., Kemp A., Burt F.J., Grobbelaar A.A., Croft J., Bausch D.G., et al. Studies of reservoir hosts for Marburg virus. Emerg Infect Dis. 2007;13:1847–1851. doi: 10.3201/eid1312.071115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Tandler B. Cytomegalovirus in the principal submandibular gland of the little brown bat, Myotis lucifugus. J Comp Pathol. 1996;114:1–9. doi: 10.1016/S0021-9975(96)80057-0. [DOI] [PubMed] [Google Scholar]
  62. Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G., Dong B.Q., Liu W., Cheung C.L., et al. Prevalence and genetic diversity of coronaviruses in bats from China. J Virol. 2006;80:7481–7490. doi: 10.1128/JVI.00697-06. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Teeling E.C., Springer M.S., Madsen O., Bates P., O’Brien S.J., Murphy W.J. A molecular phylogeny for bats illuminates biogeography and the fossil record. Science. 2005;307:580–584. doi: 10.1126/science.1105113. [DOI] [PubMed] [Google Scholar]
  64. Tjornehoj K., Fooks A.R., Agerholm J.S., Ronsholt L. Natural and experimental infection of sheep with European bat lyssavirus type-1 of Danish bat origin. J Comp Pathol. 2006;134:190–201. doi: 10.1016/j.jcpa.2005.10.005. [DOI] [PubMed] [Google Scholar]
  65. Towner J.S., Amman B.R., Sealy T.K., Carroll S.A., Comer J.A., Kemp A., Swanepoel R., Paddock C.D., Balinandi S., Khristova M.L., et al. Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog. 2009;5:e1000536. doi: 10.1371/journal.ppat.1000536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Towner J.S., Pourrut X., Albarino C.G., Nkogue C.N., Bird B.H., Grard G., Ksiazek T.G., Gonzalez J.P., Nichol S.T., Leroy E. M. Marburg virus infection detected in a common African bat. PLoS One. 2007;2:e764. doi: 10.1371/journal.pone.0000764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. van Thiel, P.P., van den Hoek, J.A., Eftimov, F., Tepaske, R., Zaaijer, H.J., Spanjaard, L., de Boer, H.E., van Doornum, G.J., Schutten, M., Osterhaus, A.. et al. (2008). Fatal case of human rabies (Duvenhage virus) from a bat in Kenya: The Netherlands, December 2007. Euro Surveill 13. [PubMed]
  68. Wacharapluesadee S., Lumlertdacha B., Boongird K., Wanghongsa S., Chanhome L., Rollin P., Stockton P., Rupprecht C.E., Ksiazek T.G., Hemachudha T. Bat Nipah virus, Thailand. Emerg Infect Dis. 2005;11:1949–1951. doi: 10.3201/eid1112.050613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Watanabe S., Ueda N., Iha K., Masangkay J.S., Fujii H., Alviola P., Mizutani T., Maeda K., Yamane D., Walid A., et al. Detection of a new bat gammaherpesvirus in the Philippines. Virus Genes. 2009;39:90–93. doi: 10.1007/s11262-009-0368-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Wibbelt G., Kurth A., Yasmum N., Bannert M., Nagel S., Nitsche A., Ehlers B. Discovery of herpesviruses in bats. J Gen Virol. 2007;88:2651–2655. doi: 10.1099/vir.0.83045-0. [DOI] [PubMed] [Google Scholar]
  71. Woo P.C., Wang M., Lau S.K., Xu H., Poon R.W., Guo R., Wong B.H., Gao K., Tsoi H.W., Huang Y., et al. Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features. J Virol. 2007;81:1574–1585. doi: 10.1128/JVI.02182-06. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Zhu H.C., Chu D.K., Liu W., Dong B.Q., Zhang S.Y., Zhang J.X., Li L.F., Vijaykrishna D., Smith G.J., Chen H.L., et al. Detection of diverse astroviruses from bats in China. J Gen Virol. 2009;90:883–887. doi: 10.1099/vir.0.007732-0. [DOI] [PubMed] [Google Scholar]

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