Skip to main content
Protein & Cell logoLink to Protein & Cell
. 2010 Aug 28;1(8):706–708. doi: 10.1007/s13238-010-0097-8

Redemystifying MST1/hippo signaling

Lei Xiao 1, Zengqiang Yuan 1,
PMCID: PMC4875199  PMID: 21203910

The content is available as a PDF (76.9 KB).

References

  1. Ahn S.H., Cheung W.L., Hsu J.Y., Diaz R.L., Smith M.M., Allis C.D. Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell. 2005;120:25–36. doi: 10.1016/j.cell.2004.11.016. [DOI] [PubMed] [Google Scholar]
  2. Anand R., Kim A.Y., Brent M., Marmorstein R. Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. Biochemistry. 2008;47:6719–6726. doi: 10.1021/bi800309m. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Badouel C., Gardano L., Amin N., Garg A., Rosenfeld R., Le Bihan T., McNeill H. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell. 2009;16:411–420. doi: 10.1016/j.devcel.2009.01.010. [DOI] [PubMed] [Google Scholar]
  4. Baumgartner R., Poernbacher I., Buser N., Hafen E., Stocker H. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell. 2010;18:309–316. doi: 10.1016/j.devcel.2009.12.013. [DOI] [PubMed] [Google Scholar]
  5. Bennett F.C., Harvey K.F. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol. 2006;16:2101–2110. doi: 10.1016/j.cub.2006.09.045. [DOI] [PubMed] [Google Scholar]
  6. Cheung W.L., Ajiro K., Samejima K., Kloc M., Cheung P., Mizzen C.A., Beeser A., Etkin L.D., Chernoff J., Earnshaw W.C., et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003;113:507–517. doi: 10.1016/S0092-8674(03)00355-6. [DOI] [PubMed] [Google Scholar]
  7. Cinar B., Fang P.K., Lutchman M., Di Vizio D., Adam R.M., Pavlova N., Rubin M.A., Yelick P.C., Freeman M.R. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007;26:4523–4534. doi: 10.1038/sj.emboj.7601872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Creasy C.L., Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 1995;167:303–306. doi: 10.1016/0378-1119(95)00653-2. [DOI] [PubMed] [Google Scholar]
  9. Dong Y., Du X., Ye J., Han M., Xu T., Zhuang Y., Tao W. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol. 2009;183:3865–3872. doi: 10.4049/jimmunol.0900678. [DOI] [PubMed] [Google Scholar]
  10. Grzeschik N.A., Parsons L.M., Allott M.L., Harvey K.F., Richardson H.E. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol. 2010;20:573–581. doi: 10.1016/j.cub.2010.01.055. [DOI] [PubMed] [Google Scholar]
  11. Kakeya H., Onose R., Osada H. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res. 1998;58:4888–4894. [PubMed] [Google Scholar]
  12. Katagiri K., Katakai T., Ebisuno Y., Ueda Y., Okada T., Kinashi T. Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J. 2009;28:1319–1331. doi: 10.1038/emboj.2009.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villén J., Becker E.B., DiBacco S., de la Iglesia N., Gygi S., Blackwell T.K., et al. A conserved MST-FOXO signaling pathway mediates oxidativestress responses and extends life span. Cell. 2006;125:987–1001. doi: 10.1016/j.cell.2006.03.046. [DOI] [PubMed] [Google Scholar]
  14. Oh S., Lee D., Kim T., Kim T.S., Oh H.J., Hwang C.Y., Kong Y.Y., Kwon K.S., Lim D.S. Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009;29:6309–6320. doi: 10.1128/MCB.00551-09. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pellock B.J., Buff E., White K., Hariharan I.K. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol. 2007;304:102–115. doi: 10.1016/j.ydbio.2006.12.021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Qiao M., Wang Y., Xu X., Lu J., Dong Y., Tao W., Stein J., Stein G. S., Iglehart J.D., Shi Q., et al. Mst1 is an interacting protein that mediates PHLPPs’ induced apoptosis. Mol Cell. 2010;38:512–523. doi: 10.1016/j.molcel.2010.03.017. [DOI] [PubMed] [Google Scholar]
  17. Robinson B.S., Huang J., Hong Y., Moberg K.H. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. Curr Biol. 2010;20:582–590. doi: 10.1016/j.cub.2010.03.019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Song H., Mak K.K., Topol L., Yun K., Hu J., Garrett L., Chen Y., Park O., Chang J., Simpson R.M., et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010;107:1431–1436. doi: 10.1073/pnas.0911409107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Taylor L.K., Wang H.C., Erikson R.L. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci U S A. 1996;93:10099–10104. doi: 10.1073/pnas.93.19.10099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Yuan Z., Kim D., Shu S., Wu J., Guo J., Xiao L., Kaneko S., Coppola D., Cheng J.Q. Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem. 2010;285:3815–3824. doi: 10.1074/jbc.M109.059675. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  21. Zhou D., Medoff B.D., Chen L., Li L., Zhang X.F., Praskova M., Liu M., Landry A., Blumberg R.S., Boussiotis V.A., et al. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008;105:20321–20326. doi: 10.1073/pnas.0810773105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Zhou D., Conrad C., Xia F., Park J.S., Payer B., Yin Y., Lauwers G.Y., Thasler W., Lee J.T., Avruch J., et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009;16:425–438. doi: 10.1016/j.ccr.2009.09.026. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Protein & Cell are provided here courtesy of Oxford University Press

RESOURCES