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. 2011 Apr 6;2(3):189–201. doi: 10.1007/s13238-011-1016-3

Animal models for the atherosclerosis research: a review

Li Xiangdong 1,✉, Liu Yuanwu 1, Zhang Hua 1, Ren Liming 1, Li Qiuyan 1, Li Ning 1,✉
PMCID: PMC4875304  PMID: 21468891

Abstract

Atherosclerosis is a leading cause of death worldwide, and its mechanisms are still unclear. However, various animal models have significantly advanced our understanding of the mechanisms involved in atherosclerosis and have allowed the evaluation of therapeutic options. The aim of this paper is to review those animal models (i.e., rabbits, mice, rats, guinea pigs, hamsters, avian, carnivores, swine, and, non-human primates) that have been used to study atherosclerosis. Though there is no single perfect animal model that completely replicates the stages of human atherosclerosis, cholesterol feeding and mechanical endothelial injury are two common features shared by most models of atherosclerosis. Further, with the development of genetically modified animals, these models are significantly broadening our understanding of the pathogenesis of atherosclerosis.

Keywords: animal model, atherosclerosis

Contributor Information

Li Xiangdong, Email: xiangdongli@cau.edu.cn.

Li Ning, Email: ninglcau@cau.edu.cn.

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