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. 2011 Apr 6;2(3):237–249. doi: 10.1007/s13238-011-1028-z

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K Verma 1,2,3, Trivadi S Ganesan 1,2, Uday Kishore 7, Peter J Parker 3,4,✉
PMCID: PMC4875310  PMID: 21468893

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

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Supplementary material is available for this article at 10.1007/s13238-011-1028-z and is accessible for authorized users.

Keywords: RASSF1A, Rap1A, microtubule, vimentin, protein-protein interaction

Electronic supplementary material

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Supplementary material, approximately 144 KB.

Footnotes

Electronic Supplementary Material

Supplementary material is available for this article at 10.1007/s13238-011-1028-z and is accessible for authorized users.

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