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. 2012 Sep 15;3(10):762–768. doi: 10.1007/s13238-012-2058-x

Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling

Kai Gong 1, Fangfang Zhou 1,2,✉, Huizhe Huang 1,3, Yandao Gong 1, Long Zhang 2,✉
PMCID: PMC4875346  PMID: 22983902

Abstract

We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) using RAW264.7 cells. LPS rapidly stimulated cytosolic β-catenin accumulation. β-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activation-primed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin accumulation. Overall, our findings suggest that suppression of GSK3β by ERK stimulates β-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.

Keywords: LPS, ERK, GSK3β, β-catenin, cell migration

Footnotes

These authors contributed equally to the work.

Contributor Information

Fangfang Zhou, Email: F.zhou@lumc.nl.

Long Zhang, Email: L.zhang@lumc.nl.

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