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. 2012 Dec 20;4(2):83–85. doi: 10.1007/s13238-012-2940-6

Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism

Wensu Liu 12940, Ming Li 12940, Jing Qu 12940, Fei Yi 22940,✉, Guang-Hui Liu 12940,✉
PMCID: PMC4875368  PMID: 23264042

Abstract

Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.

Footnotes

These authors contributed equally to the work.

Contributor Information

Fei Yi, Email: fyi@stanford.edu.

Guang-Hui Liu, Email: ghliu@ibp.ac.cn.

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