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. 2012 Jul 10;3(7):497–507. doi: 10.1007/s13238-012-0042-0

Functional regulation of monocyte-derived dendritic cells by microRNAs

Yifan Zhan 1,2,✉, Li Wu 3
PMCID: PMC4875395  PMID: 22773340

Abstract

Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a “double-edge” sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.

Keywords: dendritic cells, microRNA, function

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