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. 2012 Mar 17;3(2):117–122. doi: 10.1007/s13238-012-2018-5

Multifaceted functions of Siva-1: more than an Indian God of Destruction

Yide Mei 1,✉, Mian Wu 1,✉
PMCID: PMC4875415  PMID: 22426980

Abstract

Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.

Keywords: Siva-1, p53, apoptosis, tumor metastasis, stathmin

Contributor Information

Yide Mei, Email: meiyide@ustc.edu.cn.

Mian Wu, Email: wumian@ustc.edu.cn.

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