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. 2012 Sep 21;3(11):826–833. doi: 10.1007/s13238-012-2068-8

Direct lineage conversion: induced neuronal cells and induced neural stem cells

Zixiao Shi 1, Jianwei Jiao 1,✉
PMCID: PMC4875457  PMID: 22996174

Abstract

Cellular reprogramming to neural cells is an area of ongoing study in developmental neuroscience, and recent research has generated remarkable achievements. Several studies have shown that the ectopic expression of specific neural transcription factors can convert terminally differentiated cells into neural cells. Here, we review the most recent progress in the field of induced neuronal (iN) cells and induced neural stem (iNS) cells and their potential clinical applications.

Keywords: iN cells, iNS cells, conversion, reprogramming, neuron, fibroblast

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