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. 2012 Oct 17;3(11):811–817. doi: 10.1007/s13238-012-2083-9

New components of the necroptotic pathway

Zhenru Zhou 1, Victor Han 1, Jiahuai Han 1,✉
PMCID: PMC4875459  PMID: 23073834

Abstract

Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.

Keywords: necrosis, necroptosis, necrosome

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