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. 2012 Apr 28;3(5):372–382. doi: 10.1007/s13238-012-2021-x

The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1

Shuai Wang 1, Jing Long 1, Chun-fu Zheng 1,✉
PMCID: PMC4875467  PMID: 22544561

Abstract

Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.

Keywords: herpes simplex virus type 1 (HSV-1), reactivation, ICP0, promyelocytic leukemia (PML), speckled protein of 100 kDa (Sp100)

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