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. 2012 Apr 20;3(4):262–270. doi: 10.1007/s13238-012-2930-8

Neuronal stem cells in the central nervous system and in human diseases

Qian Wu 1,✉, Xiaoqun Wang 1,✉
PMCID: PMC4875481  PMID: 22528753

Abstract

The process of cortical expansion in the central nervous system is a key step of mammalian brain development to ensure its physiological function. Radial glial (RG) cells are a glial cell type contributing to this progress as intermediate neural progenitor cells responsible for an increase in the number of cortical neurons. In this review, we discuss the current understanding of RG cells during neurogenesis and provide further information on the mechanisms of neurodevelopmental diseases and stem cell-related brain tumorigenesis. Knowledge of neuronal stem cell and relative diseases will bridge benchmark research through translational studies to clinical therapeutic treatments of these diseases.

Keywords: radial glial cell, neuronal stem cell, tumorigenesis, glioma

Contributor Information

Qian Wu, Email: qianwu@moon.ibp.ac.cn.

Xiaoqun Wang, Email: xiaoqunwang@ibp.ac.cn.

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