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. 2013 Mar 21;4(4):251–258. doi: 10.1007/s13238-013-2128-8

Negative regulation of NLRP3 inflammasome signaling

Shuzhen Chen 12128, Bing Sun 12128,22128,✉
PMCID: PMC4875520  PMID: 23519777

Abstract

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of inflammasomes have been described, the NLRP3 inflammasome is the most extensively studied. NLRP3 inflammasome is triggered by a variety of stimuli, including infection, tissue damage and metabolic dysregulation, and then activated through an integrated cellular signal. Many regulatory mechanisms have been identified to attenuate NLRP3 inflammasome signaling at multiple steps. Here, we review the developments in the negative regulation of NLRP3 inflammasome that protect host from inflammatory damage.

Keywords: inflammasome, NLRP3, negative regulation, inflammation

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