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. 2016 Apr 2;5:e13343. doi: 10.7554/eLife.13343

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© 2016, Ray et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — Parasaggital sections showing superficial layers of the MEC processed for calbindin-immunoreactivity (green). (a) Calbindin expression is seen throughout layer 3 in P8 rats. (b) Calbindin expression is seen only in ventral half of layer 3 in P16 rats. (c) Calbindin expression is largely absent in layer 3 in adult rats. (d) Proportion of layer 3 calbindin+ neurons in dorsal (white), intermediate (gray) and ventral (black) MEC in P4-P8 (n=3776 neurons, 8 rats); P12-P16 (n =2014 neurons, 8 rats); and adult (n=828 neurons, 7 rats) rats. The numbers represent layer 3 calbindin+ neuronal density and decay in a dorsal to ventral gradient with age as evident with the reduced proportions of the white (dorsal MEC) and gray (intermediate MEC) sections of the columns with increasing age. Scale bars 250 µm. L1- Layer 1; L2- Layer 2; L3- Layer 3; D- Dorsal; V-Ventral. Orientation in (c) applies to all sections.

DOI: http://dx.doi.org/10.7554/eLife.13343.012

Figure 5—figure supplement 1. — Parasaggital sections showing superficial layers of the MEC processed for calbindin-immunoreactivity (green). (a) Calbindin expression is seen throughout layer 3 in P8 rats. (b) Calbindin expression is seen only in ventral half of layer 3 in P16 rats. (c) Calbindin expression is largely absent in layer 3 in adult rats. (d) Proportion of layer 3 calbindin+ neurons in dorsal (white), intermediate (gray) and ventral (black) MEC in P4-P8 (n=3776 neurons, 8 rats); P12-P16 (n =2014 neurons, 8 rats); and adult (n=828 neurons, 7 rats) rats. The numbers represent layer 3 calbindin+ neuronal density and decay in a dorsal to ventral gradient with age as evident with the reduced proportions of the white (dorsal MEC) and gray (intermediate MEC) sections of the columns with increasing age. Scale bars 250 µm. L1- Layer 1; L2- Layer 2; L3- Layer 3; D- Dorsal; V-Ventral. Orientation in (c) applies to all sections.

DOI: http://dx.doi.org/10.7554/eLife.13343.012