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Formation of the ATPase active site. A: The conformational changes in the N‐terminal ‘switch’ regions that accompany binding of AMPPNP facilitate docking of the M‐domain and interaction of the conserved arginine residue with the γ‐phosphate of the nucleotide. B: Docking of the M‐domain is accompanied by substantial remodeling of the catalytic loop from its structure in the isolated M‐domain.
