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. 1992 Apr 1;89(7):3060–3064. doi: 10.1073/pnas.89.7.3060

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

N Y Ip 1, C F Ibáñez 1, S H Nye 1, J McClain 1, P F Jones 1, D R Gies 1, L Belluscio 1, M M Le Beau 1, R Espinosa 3rd 1, S P Squinto 1, et al.
PMCID: PMC48803  PMID: 1313578

Abstract

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.

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