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. 1990 Jul;53(7):573–575. doi: 10.1136/jnnp.53.7.573

High incidence of endogenous depression in migraine: confirmation by tyramine test.

J Jarman 1, M Fernandez 1, P T Davies 1, V Glover 1, T J Steiner 1, C Thompson 1, F C Rose 1, M Sandler 1
PMCID: PMC488132  PMID: 2391520

Abstract

Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migraine group as a whole had significantly low values compared with 14 normal controls, due almost entirely to low values in the endogenous depressive subgroup; there were no differences between diet-sensitive and non-diet-sensitive migraine patients. Thus depression in patients with migraine seems unlikely to be secondary to migraine per se. A substantial subgroup of patients with migraine may possess an inherent predisposition to endogenous depression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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