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. 1992 Apr 1;89(7):3116–3119. doi: 10.1073/pnas.89.7.3116

Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

B Biesinger 1, I Müller-Fleckenstein 1, B Simmer 1, G Lang 1, S Wittmann 1, E Platzer 1, R C Desrosiers 1, B Fleckenstein 1
PMCID: PMC48815  PMID: 1313581

Abstract

Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpes-virus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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