Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1990 Oct;53(10):912–914. doi: 10.1136/jnnp.53.10.912

Assessment of pupillary light reflex latency and darkness adapted pupil size in control subjects and in diabetic patients with and without cardiovascular autonomic neuropathy.

P Lanting 1, J E Bos 1, J Aartsen 1, L Schuman 1, J Reichert-Thoen 1, J J Heimans 1
PMCID: PMC488257  PMID: 2266375

Abstract

Increased pupillary light reflex latencies were found more often than a reduced darkness pupil size in diabetic patients with and without abnormal cardiovascular reflexes. This finding suggests that parasympathetic pupillary dysfunction precedes sympathetic pupillary denervation in diabetic autonomic neuropathy.

Full text

PDF
912

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ewing D. J., Clarke B. F. Diagnosis and management of diabetic autonomic neuropathy. Br Med J (Clin Res Ed) 1982 Oct 2;285(6346):916–918. doi: 10.1136/bmj.285.6346.916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Friedman S. A., Feinberg R., Podolak E., Bedell R. H. Pupillary abnormalities in diabetic neuropathy. A preliminary study. Ann Intern Med. 1967 Nov;67(5):977–983. doi: 10.7326/0003-4819-67-5-977. [DOI] [PubMed] [Google Scholar]
  3. Fujii T., Ishikawa S., Uga S. Ultrastructure of iris muscles in diabetes mellitus. Ophthalmologica. 1977;174(4):228–239. doi: 10.1159/000308607. [DOI] [PubMed] [Google Scholar]
  4. Hreidarsson A. B., Gundersen H. J. The pupillary response to light in type 1 (insulin-dependent) diabetes. Diabetologia. 1985 Nov;28(11):815–821. doi: 10.1007/BF00291070. [DOI] [PubMed] [Google Scholar]
  5. Pfeifer M. A., Cook D., Brodsky J., Tice D., Parrish D., Reenan A., Halter J. B., Porte D., Jr Quantitative evaluation of sympathetic and parasympathetic control of iris function. Diabetes Care. 1982 Sep-Oct;5(5):518–528. doi: 10.2337/diacare.5.5.518. [DOI] [PubMed] [Google Scholar]
  6. Pfeifer M. A., Weinberg C. R., Cook D., Best J. D., Reenan A., Halter J. B. Differential changes of autonomic nervous system function with age in man. Am J Med. 1983 Aug;75(2):249–258. doi: 10.1016/0002-9343(83)91201-9. [DOI] [PubMed] [Google Scholar]
  7. Reulen J. P., Marcus J. T., van Gilst M. J., Koops D., Bos J. E., Tiesinga G., de Vries F. R., Boshuizen K. Stimulation and recording of dynamic pupillary reflex: the IRIS technique. Part 2. Med Biol Eng Comput. 1988 Jan;26(1):27–32. doi: 10.1007/BF02441824. [DOI] [PubMed] [Google Scholar]
  8. Smith S. A., Dewhirst R. R. A simple diagnostic test for pupillary abnormality in diabetic autonomic neuropathy. Diabet Med. 1986 Jan;3(1):38–41. doi: 10.1111/j.1464-5491.1986.tb00703.x. [DOI] [PubMed] [Google Scholar]
  9. Smith S. A., Smith S. E. Evidence for a neuropathic aetiology in the small pupil of diabetes mellitus. Br J Ophthalmol. 1983 Feb;67(2):89–93. doi: 10.1136/bjo.67.2.89. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES