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. 1990 Nov;53(11):1004–1007. doi: 10.1136/jnnp.53.11.1004

Comparison of motor response to apomorphine and levodopa in Parkinson's disease.

P A Kempster 1, J P Frankel 1, G M Stern 1, A J Lees 1
PMCID: PMC488286  PMID: 2283512

Abstract

The magnitude and pattern of motor responses to single doses of subcutaneous apomorphine and oral levodopa were compared in 14 patients with Parkinson's disease. Although apomorphine produced much shorter motor responses than levodopa, the quality of response to the two drugs was virtually indistinguishable. These clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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