Table 1.

IC₅₀ (μM) ± S.E.M.^a for compounds 1a·HCl-1c·HCl, 2a–2c and a·HCl-c·HCl in the androgen-independent prostate cancer PC-3 cells after 72 h of incubation.

Compound	IC₅₀ values
1a·HCl	121.3 ± 5.7
1b·HCl	113 ± 6.5
1c·HCl	25.7 ± 8.6
2a	139.2 ± 8.4
2b	59.3 ± 6.8
2c	17.3 ± 5.2
a·HCl	201.7 ± 9.4
b·HCl	177 ± 5.5
c·HCl	204.7 ± 15.6
[(η⁵-C₅H₅)TiCl₃]	>300

Each value represents the mean ± S.E.M. of at least three independent experiments.