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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1990 Dec;53(12):1089–1095. doi: 10.1136/jnnp.53.12.1089

Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study.

J R Hodges 1, D P Salmon 1, N Butters 1
PMCID: PMC488322  PMID: 2149861

Abstract

A controlled prospective study compared the performance of 14 patients with dementia of Alzheimer type (DAT) and 14 patients with Huntington's Disease (HD), who were matched for overall level of dementia, on a battery of semantic and episodic memory tests. The DAT patients were significantly more impaired on measures of delayed verbal and figural episodic memory, and in addition showed a more rapid rate of decline on tests which depend upon the integrity of semantic knowledge (naming, number information, similarities and category fluency). In contrast, the HD patients were significantly worse, and showed a more rapid decline on the letter fluency test, a task especially sensitive to deficiencies in retrieval. The HD patients were also more impaired than DAT patients on a vocabulary test and on copying geometric figures. The observed double dissociations offer compelling evidence that aetiologically distinct forms of dementing illness result in different patterns of cognitive impairment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albert M. L., Feldman R. G., Willis A. L. The 'subcortical dementia' of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 1974 Feb;37(2):121–130. doi: 10.1136/jnnp.37.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aminoff M. J., Marshall J., Smith E. M., Wyke M. A. Pattern of intellectual impairment in Huntington's chorea. Psychol Med. 1975 May;5(2):169–172. doi: 10.1017/s0033291700056439. [DOI] [PubMed] [Google Scholar]
  3. Bayles K. A., Tomoeda C. K. Confrontation naming impairment in dementia. Brain Lang. 1983 May;19(1):98–114. doi: 10.1016/0093-934x(83)90057-3. [DOI] [PubMed] [Google Scholar]
  4. Boll T. J., Heaton R., Reitan R. M. Neuropsychological and emotional correlates of Huntington's chorea. J Nerv Ment Dis. 1974 Jan;158(1):61–69. doi: 10.1097/00005053-197401000-00008. [DOI] [PubMed] [Google Scholar]
  5. Brouwers P., Cox C., Martin A., Chase T., Fedio P. Differential perceptual-spatial impairment in Huntington's and Alzheimer's dementias. Arch Neurol. 1984 Oct;41(10):1073–1076. doi: 10.1001/archneur.1984.04050210071017. [DOI] [PubMed] [Google Scholar]
  6. Brown R. G., Marsden C. D. 'Subcortical dementia': the neuropsychological evidence. Neuroscience. 1988 May;25(2):363–387. doi: 10.1016/0306-4522(88)90246-1. [DOI] [PubMed] [Google Scholar]
  7. Buschke H., Fuld P. A. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology. 1974 Nov;24(11):1019–1025. doi: 10.1212/wnl.24.11.1019. [DOI] [PubMed] [Google Scholar]
  8. Butters N., Albert M. S., Sax D. S., Miliotis P., Nagode J., Sterste A. The effect of verbal mediators on the pictorial memory of brain-damaged patients. Neuropsychologia. 1983;21(4):307–323. doi: 10.1016/0028-3932(83)90018-0. [DOI] [PubMed] [Google Scholar]
  9. Butters N., Granholm E., Salmon D. P., Grant I., Wolfe J. Episodic and semantic memory: a comparison of amnesic and demented patients. J Clin Exp Neuropsychol. 1987 Oct;9(5):479–497. doi: 10.1080/01688638708410764. [DOI] [PubMed] [Google Scholar]
  10. Butters N., Sax D., Montgomery K., Tarlow S. Comparison of the neuropsychological deficits associated with early and advanced Huntington's disease. Arch Neurol. 1978 Sep;35(9):585–589. doi: 10.1001/archneur.1978.00500330033006. [DOI] [PubMed] [Google Scholar]
  11. Butters N., Wolfe J., Granholm E., Martone M. An assessment of verbal recall, recognition and fluency abilities in patients with Huntington's disease. Cortex. 1986 Mar;22(1):11–32. doi: 10.1016/s0010-9452(86)80030-2. [DOI] [PubMed] [Google Scholar]
  12. Butters N., Wolfe J., Martone M., Granholm E., Cermak L. S. Memory disorders associated with Huntington's disease: verbal recall, verbal recognition and procedural memory. Neuropsychologia. 1985;23(6):729–743. doi: 10.1016/0028-3932(85)90080-6. [DOI] [PubMed] [Google Scholar]
  13. Caine E. D., Ebert M. H., Weingartner H. An outline for the analysis of dementia. The memory disorder of Huntingtons disease. Neurology. 1977 Nov;27(11):1087–1092. doi: 10.1212/wnl.27.11.1087. [DOI] [PubMed] [Google Scholar]
  14. Cummings J. L., Benson D. F. Subcortical dementia. Review of an emerging concept. Arch Neurol. 1984 Aug;41(8):874–879. doi: 10.1001/archneur.1984.04050190080019. [DOI] [PubMed] [Google Scholar]
  15. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  16. Granholm E., Butters N. Associative encoding and retrieval in Alzheimer's and Huntington's disease. Brain Cogn. 1988 Jun;7(3):335–347. doi: 10.1016/0278-2626(88)90007-3. [DOI] [PubMed] [Google Scholar]
  17. Hachinski V. C., Iliff L. D., Zilhka E., Du Boulay G. H., McAllister V. L., Marshall J., Russell R. W., Symon L. Cerebral blood flow in dementia. Arch Neurol. 1975 Sep;32(9):632–637. doi: 10.1001/archneur.1975.00490510088009. [DOI] [PubMed] [Google Scholar]
  18. Heindel W. C., Butters N., Salmon D. P. Impaired learning of a motor skill in patients with Huntington's disease. Behav Neurosci. 1988 Feb;102(1):141–147. doi: 10.1037//0735-7044.102.1.141. [DOI] [PubMed] [Google Scholar]
  19. Huff F. J., Corkin S., Growdon J. H. Semantic impairment and anomia in Alzheimer's disease. Brain Lang. 1986 Jul;28(2):235–249. doi: 10.1016/0093-934x(86)90103-3. [DOI] [PubMed] [Google Scholar]
  20. Josiassen R. C., Curry L., Roemer R. A., DeBease C., Mancall E. L. Patterns of intellectual deficit in Huntington's disease. J Clin Neuropsychol. 1982 Jul;4(2):173–183. doi: 10.1080/01688638208401127. [DOI] [PubMed] [Google Scholar]
  21. Martin A., Brouwers P., Cox C., Fedio P. On the nature of the verbal memory deficit in Alzheimer's disease. Brain Lang. 1985 Jul;25(2):323–341. doi: 10.1016/0093-934x(85)90088-4. [DOI] [PubMed] [Google Scholar]
  22. Martin A., Fedio P. Word production and comprehension in Alzheimer's disease: the breakdown of semantic knowledge. Brain Lang. 1983 May;19(1):124–141. doi: 10.1016/0093-934x(83)90059-7. [DOI] [PubMed] [Google Scholar]
  23. Mayeux R., Stern Y., Rosen J., Benson F. Is "subcortical dementia" a recognizable clinical entity? Ann Neurol. 1983 Sep;14(3):278–283. doi: 10.1002/ana.410140305. [DOI] [PubMed] [Google Scholar]
  24. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  25. Moss M. B., Albert M. S., Butters N., Payne M. Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome. Arch Neurol. 1986 Mar;43(3):239–246. doi: 10.1001/archneur.1986.00520030031008. [DOI] [PubMed] [Google Scholar]
  26. Ober B. A., Dronkers N. F., Koss E., Delis D. C., Friedland R. P. Retrieval from semantic memory in Alzheimer-type dementia. J Clin Exp Neuropsychol. 1986 Jan;8(1):75–92. doi: 10.1080/01688638608401298. [DOI] [PubMed] [Google Scholar]
  27. Salmon D. P., Shimamura A. P., Butters N., Smith S. Lexical and semantic priming deficits in patients with Alzheimer's disease. J Clin Exp Neuropsychol. 1988 Aug;10(4):477–494. doi: 10.1080/01688638808408254. [DOI] [PubMed] [Google Scholar]
  28. Shoulson I., Fahn S. Huntington disease: clinical care and evaluation. Neurology. 1979 Jan;29(1):1–3. doi: 10.1212/wnl.29.1.1. [DOI] [PubMed] [Google Scholar]
  29. Smith S., Butters N., White R., Lyon L., Granholm E. Priming semantic relations in patients with Huntington's disease. Brain Lang. 1988 Jan;33(1):27–40. doi: 10.1016/0093-934x(88)90052-1. [DOI] [PubMed] [Google Scholar]
  30. Weingartner H., Caine E. D., Ebert M. H. Imagery, encoding, and retrieval of information from memory: some specific encoding--retrieval changes in Huntington's disease. J Abnorm Psychol. 1979 Feb;88(1):52–58. doi: 10.1037//0021-843x.88.1.52. [DOI] [PubMed] [Google Scholar]
  31. Weingartner H., Grafman J., Boutelle W., Kaye W., Martin P. R. Forms of memory failure. Science. 1983 Jul 22;221(4608):380–382. doi: 10.1126/science.6867715. [DOI] [PubMed] [Google Scholar]
  32. Whitehouse P. J. The concept of subcortical and cortical dementia: another look. Ann Neurol. 1986 Jan;19(1):1–6. doi: 10.1002/ana.410190102. [DOI] [PubMed] [Google Scholar]

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