Table 2.

Selected transcripts identified by RNA-seq in differentiating control and Cited2 shRNA-treated Rcho-1 TS cells

Gene Description	Gene Symbol	Biological properties	Chromosome	Cited2 shRNA/ Control shRNA
Trophoblast specific protein alpha	Tpbpa	Related to cysteine-type endoprotease	17	12.1
Matrix metallopeptidase 12	Mmp12	Metalloelastase, ECMa, coagulation	8	8.1
Egl-9 family hypoxia-inducible factor 3	Egln3	Prolyl hydroxylase, hypoxia signaling	6	5.5
Prolactin family 8, subfamily a, member 5	Prl8a5	Cytokine, hormone	17	5.0
Thrombomodulin	Thbd	Thrombin receptor, coagulation	3	4.5
Apolipoprotein A-IV	Apoa4	Lipid metabolism	8	4.4
TIMP metalloproteinase inhibitor 3	Timp3	Inhibitor of matrix metallopeptidases, ECM	7	3.6
Keratin 15	Krt15	Intermediate filaments, epithelial cells	10	3.3
Coagulation factor 3	F3	Coagulation	2	3.2
Prolactin family 8, subfamily a, member 9	Prl8a9	Cytokine, hormone	17	3.2
Interleukin 1 receptor, type II	Il1r2	Decoy receptor for IL-1 ligands	9	2.6
PX domain containing 1	Pxdc1	Phosphatidylinositol binding	17	2.5
Argininoscuccinate synthase 1	Ass1	Arginine biosynthetic pathway	3	0.37
Mesoderm specific transcript	Mest	Hydrolase superfamily, imprinted, developmentally regulated	4	0.34
Protein tyrosine phosphatase, receptor type K	Ptprk	Signaling pathway controlling cell-cell adhesion, growth control, invasion	1	0.30
Topoisomerase (DNA) II alpha	Top2a	Nuclear protein regulating chromosome dynamics	10	0.17
CREBBP/EP300-interacting transactivator, with Glu/Asp-rish carboxy-terminal domain, 2	Cited2	Transcription co-regulator	1	0.16

^aECM, extracellular matrix