Extended Data Figure 6. Structural signatures of inner ring scaffold Nups and membrane binding motifs of Nup160 and Nup133.

(a) Same as Fig. 3a but for the CR. (b) Fits of Nup160 (left) of the outer (orange) and inner (grey) Y-complexes into the NR are shown. Additional density accounting for the C-terminal domain of Elys is indicated. Fits of Nup133 are shown at normal (center) and high (right) isosurface thresholds. At the higher isosurface threshold, density linking both Nup133 domains is apparent also in the outer stem. The membrane-binding motifs ²⁸ are colored red. Asterisks mark structures that can be unambiguously positioned but have some uncertainty in their orientation. Those are the beta propellers of Elys and Nup133 as well as Nup85-CTD.